Table 1.
MIC values (µg/mL) of the phytochemical-based TPP+ conjugates 5a-x, 11a-f and reference antibiotics against the selected microorganisms.
| Series | Compound | R | n2 | MIC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| S. aureus | E. coli | K. pneumoniae | P. aeruginosa | A. baumannii | C. albicans | C.neoformans | ||||
|
A |
5a | H | 1 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| 5b | OH | 1 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5c | H | 2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5d | OH | 2 | 32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5e | H | 3 | 8 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5f | OH | 3 | 16 | >32 | >32 | >32 | >32 | >32 | >32 | |
|
B |
5g | H | 1 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| 5h | OH | 1 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5u | H | 2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5v | OH | 2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5i | H | 3 | 8 | >32 | >32 | >32 | >32 | 32 | >32 | |
| 5j | OH | 3 | 8 | >32 | >32 | >32 | >32 | >32 | 32 | |
|
C |
5k | H | 1 | 32 | >32 | >32 | >32 | >32 | >32 | >32 |
| 5l | OH | 1 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5w | H | 2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5x | OH | 2 | 8 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5m | H | 3 | ≤0.25 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5n | OH | 3 | ≤0.25 | >32 | >32 | >32 | >32 | >32 | >32 | |
|
D |
5o | H | 1 | >32 | >32 | >32 | >32 | >32 | >32 | >32 |
| 5p | OH | 1 | >32 | >32 | >32 | >32 | >32 | >32 | 16 | |
| 5q | H | 2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 5r | OH | 2 | 32 | >32 | >32 | >32 | >32 | >32 | 16 | |
| 5s | H | 3 | 8 | >32 | >32 | >32 | >32 | 16 | 16 | |
| 5t | OH | 3 | 16 | >32 | >32 | >32 | >32 | 16 | 4 | |
|
E |
11a | H | 1 | >32 | >32 | >32 | >32 | >32 | 32 | >32 |
| 11b | OH | 1 | 32 | >32 | >32 | >32 | >32 | >32 | 32 | |
| 11c | H | 2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | |
| 11d | OH | 2 | 16 | >32 | >32 | >32 | >32 | >32 | 8 | |
| 11e | H | 3 | 16 | >32 | >32 | >32 | >32 | 32 | >32 | |
| 11f | OH | 3 | 2 | >32 | >32 | >32 | >32 | 8 | 4 | |
| Colistin | __ | __ | >32 | 0.125 | 0.25 | 0.25 | 0.25 | n.d. | n.d. | |
| Vancomycin | __ | __ | 1 | >32 | >32 | >32 | >32 | n.d. | n.d. | |
| Fluconazole | __ | __ | n.d. | n.d. | n.d. | n.d. | n.d. | 0.125 | 8 | |
Standard strains: S. aureus ATCC 43300; E. coli ATCC 25922, K. pneumoniae ATCC 70060, P. aeruginosa ATCC 27853, A. baumannii ATCC 19606, C. albicans ATCC 90028, and C. neoformans var. grubii H99 ATCC 208821.
n.d.: not determined.