Figure 3.

Role of A1 in hyperoxia-induced TUNEL⁺ cell death and DNA injury. Tg(–) and Tg(+) mice with (+/+) and (–/–) A1 loci were exposed for 72 hours to room air (white bars) or 100% O₂ (black bars), and TUNEL evaluations were undertaken. The TUNEL evaluations in A–D are representative of a minimum of 9 similar evaluations. The arrows highlight representative TUNEL⁺ cells. The values in E are the mean ± SEM of evaluations in a minimum of 9 mice. *P < 0.05; **P < 0.01.