Figure 8.

Induction of A1 and its role in VEGF cytoprotection. Lungs were obtained from Tg(–) and VEGF Tg(+) mice on doxycycline water for 1 month. (A) A1 mRNA was quantitated by RPA. (B) A1 protein was evaluated by Western blot analysis. (C) The survival of Tg(–) mice (open squares) and VEGF Tg(+) mice with (+/+) (filled diamonds) and (–/–) (open diamonds) A1 loci in 100% O₂. A and B are representative of a minimum of 4 similar evaluations. The values in C illustrate the survival of a minimum of 6 mice at each time point. P, multiprobe template. **P < 0.05.