Table 2. Pregnancy, Fetal, and Obstetric Outcomes in Patients With a Pregnancy After Breast Cancer.
| Outcomes | No. (%) (n = 659) |
|---|---|
| Age at pregnancy, median (IQR), y | 34.7 (31.8-37.3) |
| Time from diagnosis to conception, median (IQR) y | 3.5 (2.2-5.3) |
| Pregnancy interval | |
| ≤2 Years after diagnosis | 131 (19.9) |
| Between >2 and ≤5 years after diagnosis | 345 (52.4) |
| >5 Years after diagnosis | 183 (27.8) |
| Type of conception | |
| Spontaneous pregnancy | 461/582 (79.2) |
| Use of assisted reproductive technology | 121/582 (20.8) |
| Embryo transfer after oocyte/embryo cryopreservation at diagnosis of breast cancer | 48 |
| Embryo transfer following oocyte donation | 29 |
| Ovarian stimulation for IVF/ICSI/ovulation induction after anticancer treatment | 36 |
| Unknown type of assisted reproductive technology | 8 |
| Pregnancy outcome | n = 649 |
| Delivered | 517 (79.7) |
| Ongoing pregnancy | 24 (3.7) |
| Miscarriage | 63 (9.7) |
| Induced abortion | 45 (6.9) |
| No. of live births from first pregnancy after breast cancera | n = 517 |
| 1 | 463 (89.6) |
| 2 | 54 (10.4) |
| Timing of deliverya | n = 446 |
| At term (≥37 wk) | 406 (91.0) |
| Preterm (<37 wk) | 40 (9.0) |
| Complicationsa | n = 423 |
| None | 365 (86.3) |
| Pregnancy complications | 27 (6.4) |
| Delivery complications | 22 (5.2) |
| Congenital abnormalitiesb,c | 4 (0.9) |
| Fetal complicationsb,c | 3 (0.6) |
| Other complicationsc | 2 (0.5) |
| Breastfeedinga | 133/403 (33.0) |
| Duration, median (IQR), mo | 5 (2-6) |
| Unknown, No. | 50 |
Abbreviations: IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection.
a
Calculated from the total number of delivered pregnancies.
b
Calculated from the total number of infants born to patients with known information on pregnancy complications (n = 470).
c
Congenital abnormalities included cardiac malformation (n = 2), congenital diaphragmatic hernia (n = 1), and chromosome abnormality with karyotype 47,XXY (n = 1). Fetal complications included respiratory distress (n = 2) and neonatal icterus treated with phototherapy (n = 1). Other complications included maternal internal carotid artery aneurysm (n = 1) and kidney failure in the infant due to hypoxia (n = 1).