Fig. 8.

Schematic illustration of PEG–PEI nanogel (NG), which is selectively internalized in the activated astrocytes and limits the inflammatory response. (A) Following 24-h exposure, a substantial quantity of PEG-PEI NG is observed within the cytoplasm of astrocytes. (B) PEG-PEI NG has been seen to decrease the expression of inducible nitric oxide synthase (iNOS) and lipocalin 2 (Lcn2) in activated astrocytes. (C) Early administration of NG loaded with rolipram demonstrated enhanced locomotor ability in mice with TSCI. Copyright 2020 ACS Nano [20].