Table 2. Circulating Immunocyte Markers Predictive of Neuronal Injury Scoresa.
| cell types | injury scores | by neuronal injury categories (mean ± SEM) | by neuronal inflammation categories (mean ± SEM) | predictive cutoffs for worse outcomes |
|---|---|---|---|---|
| 0 | 15.1 ± 0.9 | 15.0 ± 1.0 | ||
| CD3+CD8+ | 1 | 18.9 ± 1.0 | 17.3 ± 1.1 | >18% |
| 2 | 19.1 ± n/a | 18.7 ± 1.4 | ||
| 0 | 3.6 ± 0.2 | 3.7 ± 0.2 | ||
| CD4+CD25+ | 1 | 5.2 ± 0.4 | 4.4 ± 0.8 | >4% |
| 2 | 5.4 ± n/a | 5.1 ± 0.5 | ||
| 0 | 16.1 ± 2.0 | |||
| CD45+CD11b+ | 1 | NS | 18.0 ± 3.2 | >18% |
| 2 | 25.2 ± 2.0 | |||
| 0 | 13.0 ± 1.6 | |||
| CD45+CD11b+CD11c– | 1 | NS | 14.9 ± 2.6 | >15% |
| 2 | 21.8 ± 1.9 | |||
| 0 | NS | 1.1 ± 0.1 | ||
| CD11b+Ly6C+Ly6G+ | 1 | 1.0 ± 0.2 | >1% | |
| 2 | 2.3 ± 0.2 | |||
| 0 | 14.6 ± 1.7 | 14.5 ± 2.0 | ||
| CD80+ | 1 | 12.5 ± 2.5 | 13.1 ± 2.0 | <13% |
| 2 | 9.8 ± n/a | 11.8 ± 1.3 | ||
| 0 | 3.8 ± 0.9 | |||
| CD86+ | 1 | NS | 3.8 ± 1.5 | <3% |
| 2 | 2.6 ± 0.5 | |||
| 0 | 40.5 ± 3.5 | |||
| F4/80 | 1 | NS | 38.8 ± 3.7 | <35% |
| 2 | 25.9 ± 2.4 |
a
“0” indicates normal levels of injury or inflammation, e.g., in naïve and sham animals. “1” indicates moderate injury or inflammation. “2” indicates severe levels of injury or inflammation. n/a indicates a single animal in this rank. NS = not significant.