TABLE 3.
Emerging role of circular RNAs in COPD.
| Name of the CircRNA | Expression level | Key role | Mechanisms | References |
|---|---|---|---|---|
| Circ-HACE1 | ↑ in the lung of smokers without or with COPD and 16HBE cells exposed to CSE | Promotes CSE-induced 16HBE cells injury | By modulating TLR4 by Sponging miR-485-3p | Zhou et al. (2021a) |
| CircFOXO3 | ↑ in CS-exposed lungs and CSE-exposed murine alveolar epithelial cells | Silencing ameliorates inflammatory response in the lungs of CS-exposed mice | CircFOXO3/miR-214-3p/NF-κB signaling pathway | Zhou et al. (2021b) |
| CircBbs9 | ↑ in the lung of PM2.5 exposed and COPD model in mice | Promotes PM2.5-induced lung inflammation in mice | Through activation of NLRP3 inflammasome via regulating miR-30e-5p-Adar | Li et al. (2020) |
| Circ_0008672 | ↑ in PBMCs of COPD patients | targetes NOD-like receptor signaling pathway, natural killer cell-mediated cytotoxicity, and Th17 cell differentiation | circ_0008672/miR-1265/MAPK1 signaling axis in COPD | Duan et al. (2020) |
| circ-BPTF | ↑ in the pulmonary arteries of COPD patients | Promotes hypoxic PASMC proliferation | Circ-BPTF/miR-486-5p/CEMIP axis | Wang et al. (2022b) |
| Circ_0006892 | ↓ in the lung of smokers with COPD and 16HBE cells exposed to CSE | Regulates 16HBE cells apoptosis and inflammation | Via modulating miR-24/PHLPP2 axis | Zhang et al. (2022) |
| Circ_OSBPL2 | ↑ in the lung of smokers with or without COPD and CSE-treated HBECs | facilitates apoptosis, inflammation, and oxidative stress | Via miR-193a-5p/BRD4 axis | Zheng et al. (2021) |
| ↑ in the serum of smokers with and without COPD | Promotes 16HBE cells dysfunction | By regulating miR-515-5p/IGFBP3 axis | Miao et al. (2022) | |
| CircANKRD11 | ↑ in the lung tissues of smokers with or without COPD and HPMECs exposed to CSE | knockdown attenuates HPMECs apoptosis, inflammation, and oxidative stress | by regulating miR-145-5p/BRD4 Axis | Wang et al. (2021b) |
| Circ_0006872 | ↑ in the lung of smokers with and without COPD | Promotes apoptosis, inflammation, and oxidative stress in HPMECs and BEAS-2B cells | By modulating miR-145-5p/NF-κB pathway | Xue et al. (2021) |
| Circ_0061052 | ↑ in CSE-treated 16HBE | Regulates airway remodeling and EMT | Circ_0061052/miR-515-5p/FoxC1/Snail axis | Ma et al. (2020) |
| Circ-RBMS1 | ↑ in COPD patients and 16HBECs exposed to CSE | Silencing attenuates apoptosis, inflammation, and oxidative stress | Circ-RBMS1/miR-197-3p/FBXO11 axis | Qiao et al. (2021) |
| circXPO1 | ↑ in the lungs of CS-exposed mice and CSE exposed AT2 cell line | Inhibition attenuates inflammation and cellular senescence | CircXPO1/miR-23b-3p/TAB3 signaling axis | Du et al. (2022) |
| Circ_0026466 | ↑ in the blood of smokers with COPD and CSE-induced HBECs | Knockdown attenuates CSE-induced inhibition of the viability and proliferation of HBECs and induced cell apoptosis, inflammation, and oxidative stress | Circ_0026466/miR-153-3p/TRAF6/NF-κB pathway | Wang et al. (2023b) |