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PICO framework.
| PICO Question | |
|---|---|
| Problem | Research object: patients with brain diseases |
| Intervention | Application of a theory or method; treatment with PDT, an overview of the most commonly used photosensitizers |
| Comparison | Alternative theories or methods (or, in their absence, the null hypothesis); review not only clinical trials but also pre-clinical in vitro studies |
| Outcome | Knowledge generation: increase in the effectiveness of PDT |
