Table 2.

Interventions to reduce heparin-induced thrombocytopenia incidence.

Intervention Type	Author	Year	Country	Intervention details	Preintervention group	Postintervention group	Findings
Replace UFH with LMWH
	McGowan et al. [19]	2016	Canada	Institution-wide “avoid heparin” program, including: •Replacement of most UFH with LMWH in prophylactic or therapeutic doses. •Replacement of heparinized saline in arterial and central venous lines with saline flushes. •Modifications of order sets to exclude UFH options. •Removal of UFH stores from most nursing units.	Historical controls	1118 patients with suspected HIT	•42% decrease in annual rate of suspected HIT (85.5 vs 49.0 per 10,000 admissions, P < .001) •63% decrease in positive HIT assays (16.5 vs 6.1 per 10,000 admissions, P < .001) •79% decrease in adjudicated HIT (10.7 vs 2.2 per 10,000 admissions, P < .001) •91% decrease in HITT (4.6 vs 0.4 per 10,000 admissions, P < .001) •$266,938 decrease in HIT-related expenditures per year in postintervention phase.

HIT, heparin-induced thrombocytopenia; HITT, heparin-induced thrombocytopenia with thrombosis; LMWH, low-molecular-weight heparin; UFH, unfractionated heparin.