Table 4.

Differential diagnosis for lipodystrophies

A. Generalized lipodystrophies

1. Conditions presenting with severe weight loss:

a. Malnutrition

b. Anorexia nervosa

c. Thyrotoxicosis

d. Adrenocortical insufficiency

e. Cancer cachexia

f. HIV-associated wasting

g. Chronic infections.

2. Insulin receptor mutations: Rabson-Mendenhall syndrome and Donohue syndrome

3. Severe uncontrolled T1DM or T2DM with marked weight loss due to extreme hyperglycemia

4. Acromegaly

5. Pancreatic diabetes due to exocrine and endocrine pancreatic insufficiency

B. Partial Lipodystrophies:

1. Cushing’s syndrome

2. Truncal obesity

3. Multiple symmetric lipomatosis