Table 2.

Features and functions of gasdermin family

Human gasdermin	Mouse gasdermin	Activated by	Tissue expression	Related cancers
GSDMA	Gsdma1, Gsdma2, Gsdma3	streptococcal pyrogenic exotoxin B	Skin, gastrointestinal tract	Gastric cancer, ovarian cancer
GSDMB	N	GZMA, GZMB, caspase3/6/7	Normal tissues and tumor cells	Gastric cancer, cervical cancer, hepatocarcinoma, bladder cancer, clear cell renal cell carcinoma, bladder cancer
GSDMC	Gsdmc1, Gsdmc2, Gsdmc3, Gsdmc4	Caspase8	Melanoma cells	Melanoma, lung adenocarcinoma, breast cancer, gastric cancer, colorectal cancer, kidney clear cell cancer
GSDMD	Gsdmd	Caspase1/4/5/8/11, neutrophil elastase, cathepsin G	Nucleus, plasma membrane	Hepatocellular carcinoma, non-small lung cancer, gastric cancer,
GSDME	Gsdme	Caspase3	Plasma membrane, mitochondrial	Breast cancer, lung adenocarcinoma, oesophageal squamous cell carcinoma, oral squamous cell carcinoma, colorectal cancer,