Table 1.

Reaction Optimization

entry	deviation from standard conditionsa	aziridine conversion [%]b	yield [%]b	B:Lb
1	none	100	81	12:1
2	R = Ac	100	31	1:6
3	R = Boc	96	33	1:3
4	R = Cbz	100	13	1:1
5	CpTiCl3	88	40	3:1
6	TMSCl instead of Ti	36	< 5	–
7	TiCl4•THF2	80	24	1:1
8	Cp2TiCl2	47	<5	–
9	(Cp*)2TiCl2	34	<5	–
10	Mn	93	71	11:1
11	TDAE	100	81	11:1
12	without Ni/ligand	100	0	–
13	without ligand	100	9	11:1
14	without Cp*TiCl3	32	<5	–
15	wtihout NEt3•HBr	100	34	9:1
16	without Zn	86	0	–

^aNEt₃•HBr (2.0 equiv), Zn (3.0 equiv), THF (0.15 M).

^bReactions performed on 0.1 mmol scale. Yields and selectivity were determined by GC-FID with dodecane as an internal standard.