Table 3.
Summary of the treatment schemes, light fluence rate (ϕ), in vivo photosensitizer concentration ([S0]), in vivo tumor oxygen concentration ([3O2]), and local control rate (LCR) for each PDT group with [ROS]rx > 1.1 mM excluded.
| Groups | # of Mice |
Time (s) | [S0]0 (μM) |
[S0]end (μM) |
PDT Dose (μMJ/cm2) |
Mean [ROS]rx (mM) |
LCR |
|---|---|---|---|---|---|---|---|
| Control | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 1 | 7 | 400 s + 1400 s | 4.3 ± 1.1 | 1.9 ± 1.0 | 318.4 ± 111.3 | 0.74 ± 0.20 | 0.14 ± 0.14 |
| 2 | 7 | 600 s + 1200 s | 5.0 ± 1.6 | 1.7 ± 0.8 | 320.5 ± 72.4 | 0.73 ± 0.14 | 0.14 ± 0.14 |
| 3 | 7 | 800 s + 1000 s | 4.3 ± 1.1 | 1.8 ± 0.9 | 297.5 ± 113.9 | 0.76 ± 0.16 | 0.57 ± 0.14 |
| 4 | 5 | 1000 s + 800 s | 5.9 ± 2.0 | 2.4 ± 1.0 | 459.4 ± 82.5 | 0.66 ± 0.18 | 0.40 ± 0.20 |
| 5 | 4 | 1200 s + 600 s | 6.3 ± 1.9 | 1.9 ± 0.6 | 394.4 ± 79.9 | 0.71 ± 0.17 | 0.25 ± 0.25 |
| 6 | 8 | 1800 s | 4.5 ± 2.1 | 1.4 ± 0.6 | 286.5 ± 62.6 | 0.59 ± 0.18 | 0.00 ± 0.12 |
| 7 | 5 | 800 s + 1600 s | 2.2 ± 0.7 | 0.9 ± 0.5 | 222.8 ± 101.0 | 0.78 ± 0.16 | 0.20 ± 0.20 |
| 8 | 5 | 1000 s + 1400 s | 3.7 ± 1.5 | 1.1 ± 0.4 | 308.0 ± 103.1 | 0.85 ± 0.16 | 0.80 ± 0.20 |
| 9 | 6 | 1200 s + 1200 s | 3.5 ± 0.9 | 2.0 ± 1.0 | 381.7 ± 68.4 | 0.84 ± 0.15 | 0.50 ± 0.17 |
| 10 | 5 | 1400 s + 1000 s | 3.9 ± 2.4 | 1.7 ± 0.5 | 380.2 ± 89.2 | 0.76 ± 0.11 | 0.40 ± 0.20 |
| 11 | 10 | 2400 s | 3.8 ± 1.9 | 1.2 ± 0.7 | 340.1 ± 47.1 | 0.86 ± 0.17 | 0.10 ± 0.10 |
| 12 | 1 | 1400 s + 1600 s | 4.1 | 2.4 | 606.5 ± 210.9 | 1.01 | 1.0 |
| 13 | 1 | 3000 s | 3.7 | 1.2 | 427.4 ± 202.7 | 0.96 | 0 |