Table 5.
The association between biomarkers of systemic inflammation combined with the occurrence of irAEs and progression-free survival and overall survival in all patients. Bold/italics represent statistically significant associations in this table and others.
| Progression-Free Survival | Overall Survival | ||||||
|---|---|---|---|---|---|---|---|
| Without irAE | With irAE | HR (95% CI) p |
Without irAE | With irAE | HR (95% CI) p |
||
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | ||||
| SIPS | 0 | 7.6 (2.7–23.3) | 14.7 (5.3-n/r) |
0.57 (0.36–0.91)
0.015 |
14.0 (2.8–5.3) | 34.3 (18.9-n/r) |
0.40 (0.24–0.67)
0.001 |
| 1 | 3.6 (1.8–13.6) | 19.5 (7.1–45.4) |
0.38 (0.22–0.64)
<0.001 |
8.2 (3.0–21.5) | 23.6 (12.3-n/r) |
0.40 (0.24–0.69)
0.001 |
|
| 2 | 1.6 (0.8–4.0) | 8.1 (7.5–28.8) |
0.26 (0.11–0.64)
0.003 |
2.9 (1.5–9.2) | 16.7 (7.5–33.2) |
0.35 (0.16–0.81)
0.013 |
|
| HR (95% CI) p |
1.75 (1.43–2.14)
<0.001 |
1.15 (0.78–1.69) 0.479 |
1.67 (1.37–2.04)
<0.001 |
1.53 (1.03–2.28)
0.037 |
|||
| White Cell Count | ≤11.0 × 109/L | 4.6 (1.8–16.4) | 15.6 (5.9–45.4) |
0.50 (0.35–0.72)
<0.001 |
10.1 (4.1–28.2) | 32.2 (14.3-n/r) |
0.43 (0.29–0.63)
<0.001 |
| >11.0 × 109/L | 1.6 (0.9–6.0) | 19.6 (7.5-n/r) |
0.27 (0.14–0.51)
<0.001 |
4.1 (1.7–11.8) | 25.5 (7.5-n/r) |
0.28 (0.14–0.53)
<0.001 |
|
| HR (95% CI) p |
1.74 (1.26–3.40)
0.001 |
0.85 (0.45–1.62) 0.621 |
1.80 (1.30–2.49)
<0.001 |
1.05 (0.53–2.07) 0.896 |
|||
| Neutrophil Count | ≤7.5 × 109/L | 11.0 (6.0–14.9) | 20.4 (15.6–27.1) |
0.54 (0.38–0.78)
0.001 |
10.7 (4.5–31.0) | 32.2 (14.3-n/r) |
0.46 (0.31–0.68)
<0.001 |
| >7.5 × 109/L | 3.3 (1.6–5.2) | 17.9 (19.6–28.8) |
0.25 (0.13–0.47)
<0.001 |
4.1 (1.6–10.4) | 25.5 (7.5-n/r) |
0.26 (0.13–0.49)
<0.001 |
|
| HR (95% CI) p |
2.11 (1.54–2.91)
<0.001 |
0.83 (0.44–1.57) 0.560 |
2.02 (1.46–2.78)
<0.001 |
1.06 (0.54–2.09) 0.868 |
|||
| Albumin | ≥35 g/L | 6.0 (1.7–23.0) | 17.1 (5.9-n/r) |
0.48 (0.32–0.73)
0.001 |
11.0 (4.6–32.6) | 43.9 (19.2-n/r) |
0.35 (0.22–0.56)
<0.001 |
| <35 g/L | 2.5 (1.2–5.9) | 14.3 (5.9–26.5) |
0.35 (0.22–0.57)
<0.001 |
4.7 (1.7–11.7) | 16.7 (8.0–32.6) |
0.42 (0.26–0.67)
<0.001 |
|
| HR (95% CI) p |
1.97 (1.43–2.72)
<0.001 |
1.53 (0.89–2.61) 0.123 |
1.88 (1.37–2.59)
<0.001 |
2.30 (1.29–4.10)
0.005 |
|||