Table 1.
Distribution of baseline patient characteristics and association with median-correct reaction time (ERTOMDCRT) at 6 months.
| Variable | Baseline Cohort n = 51 N (%) or Median (IQR *) |
Subjects with Evaluable 6-Month Data n = 38 N (%) or Median (IQR *) |
Median 6-Month ERTOMDCRT (IQR *) or Correlation Coefficient |
p-Value |
|---|---|---|---|---|
| Whole Cohort | 51 (100%) | 38 (100%) | 1381.3 (498.5) | . |
| Sex | 0.73 ^ | |||
| Male | 20 (39%) | 14 (37%) | 1381.3 (529.5) | |
| Female | 31 (61%) | 24 (63%) | 1357.3 (491.3) | |
| Handedness | 0.44 ^ | |||
| Right | 46 (90%) | 34 (89%) | 1406.3 (490.0) | |
| Left or ambidextrous | 5 (10%) | 4 (11%) | 1133.8 (375.8) | |
| Tumor histology | 0.02 ^ | |||
| Meningioma | 20 (39%) | 15 (39%) | 1421.0 (344.0) | |
| Schwannoma | 16 (31%) | 13 (34%) | 1095.5 (431.0) | |
| Glioma | 5 (10%) | 3 (8%) | 1619.5 (1290.0) | |
| Pituitary adenoma | 5 (10%) | 3 (8%) | 1570.0 (899.5) | |
| Other benign or low-grade tumor | 5 (10%) | 4 (11%) | 1797.8 (757.5) | |
| Tumor grade | 0.45 ^ | |||
| Grade 1 or presumed grade 1 via imaging | 39 (73%) | 29 (76%) | 1297.0 (501.0) | |
| Grade 2 or n/a | 12 (22%) | 9 (24%) | 1533.5 (340.5) | |
| Tumor laterality | 0.07 ^ | |||
| Right | 18 (35%) | 12 (32%) | 1229.8 (442.3) | |
| Left | 22 (43%) | 16 (42%) | 1285.3 (528.0) | |
| Bilateral or midline | 11 (22%) | 10 (26%) | 1558.5 (545.5) | |
| Race | 0.42 ^ | |||
| White | 43 (84%) | 32 (84%) | 1267.5 (557.5) | |
| Black or African-American | 6 (12%) | 5 (13%) | 1480.0 (73.0) | |
| Asian or Pacific Islander | 2 (4%) | 1 (3%) | 1203 | |
| Received chemotherapy | 0.45 ^ | |||
| Yes | 4 (8%) | 3 (8%) | 1619.5 (1290.0) | |
| No | 47 (92%) | 35 (92%) | 1367.5 (483.5) | |
| Surgical resection | 0.08 ^ | |||
| Yes | 19 (37.2%) | 13 (34.2%) | 1545.0 (398.0) | |
| No | 32 (62.8%) | 25 (65.8%) | 1238.0 (534.0) | |
| Time from surgery to RT start (months) | 15.7 (37.5) | 14.9 (36.1) | 0.29 | 0.35 ** |
| Total prescribed RT dose (Gy) | 21 (36) | 23 (36) | 0.37 | 0.02 ** |
| Total prescribed RT dose category | 0.08 ^ | |||
| >20 Gy | 29 (57%) | 23 (61%) | 1472.0 (416.5) | |
| ≤20 Gy | 22 (43%) | 15 (39%) | 1179.0 (543.5) | |
| Number of RT fractions (all) | 3 (26) | 3 (26) | 0.33 | 0.05 ** |
| Type of fractionation | 0.20 ^ | |||
| Conventional fractionation (>5 fractions) | 22 (43%) | 17 (45%) | 1533.5 (348.5) | |
| Hypofractionation (≤5 fractions) | 29 (57%) | 21 (55%) | 1233.0 (434.0) | |
| Age (years) | 58 (17) | 58 (18) | 0.49 | 0.0016 ** |
| Age category | 0.01 ^ | |||
| ≥60 years | 22 (43%) | 16 (42%) | 1546.0 (605.8) | |
| <60 years | 29 (57%) | 22 (58%) | 1191.0 (552.0) | |
| PHQ2 (all) | 1 (2) | 1 (2) | 0.04 | 0.85 ** |
| PHQ2 score category | 0.39 ^ | |||
| ≥2 | 16 (31%) | 13 (34%) | 1238.0 (577.0) | |
| <2 | 35 (69%) | 25 (66%) | 1395.0 (490.0) | |
| Baseline ERTOMDCRT | 0.62 | <0.0001 ** |
^ Wilcoxon rank sum test; * interquartile range; ** Spearman correlation.