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[Preprint]. 2024 Apr 12:2023.01.09.523321. [Version 3] doi: 10.1101/2023.01.09.523321

PMC10705271.2; 2023 Nov 28
PMC10705271.3; 2024 Apr 12

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Figure 5. — A, TOB1-AS1 expression in pancreatic cancer cell lines in CCLE. The cell lines in red are selected for further studies. B and C, 3D genomic interactions in four pancreatic cancer cell lines. Black arrows represent SVs with off-diagonal interactions. The locations of TOB1-AS1 are marked by blue lines. In Panc 10.05, the blue arrow points to the CNV breakpoint and the dashed blue triangle represents the neo-subdomain formed due to the foldback inversion. D, The reference chromosome 17 and derived chromosomes in Panc 10.05. The chromosomes are not to scale. TOB1-AS1 is shown as small blue boxes in the chromosomes. E, Open chromatin measured by ATAC-Seq in PATU-8988S and PATU-8988T at the TOB1-AS1 locus.