Figure 4.

Protein networks and significantly associated pathways for genes that are sites of HPV integration and mutated in cervical cancer: (a) proteins significantly associated with human papillomavirus infection (yellow nodes); (b) proteins significantly associated with cancer-related conditions (yellow nodes); (c) anti-cancer drugs (diamond-shaped green nodes). Other nodes (besides the yellow colored nodes in (a,b) are shown to have functional and regulatory relations with the yellow colored nodes. Note: A cancer-related condition is a disorder either associated with an increased risk of malignant transformation (e.g., intraepithelial neoplasia, leukoplakia, dysplastic nevus, and myelodysplastic syndrome) or that develops as a result of the presence of an existing malignant neoplasm (e.g., paraneoplastic syndrome).