Table 3.
Heritability and ANOVA results for oxycodone SA parameters
| Phenotype | Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|---|
| h2 | Df | F | p | h2 | Df | F | p | ||
| FR5, 0.025mg, 1h | Active Lick | 0.302 | (25,441) | 7.77 | 1.3E-22 | 0.368 | (32,588) | 10.87 | 2.2E-41 |
| Inactive Lick | 0.216 | (25,436) | 5.20 | 8.4E-14 | 0.227 | (32,579) | 5.89 | 3.0E-20 | |
| Reward | 0.341 | (25,441) | 9.13 | 4.9E-27 | 0.261 | (32,588) | 6.99 | 4.0E-25 | |
| Intake | 0.347 | (25,432) | 9.07 | 9.5E-27 | 0.287 | (32,570) | 7.45 | 5.3E-27 | |
| FR5, 0.025mg, 4h | Active Lick | 0.297 | (25,277) | 5.34 | 3.3E-13 | 0.411 | (32,376) | 8.71 | 2.9E-29 |
| Inactive Lick | 0.081 | (25,272) | 1.86 | 9.0E-03 | 0.252 | (32,366) | 4.63 | 1.2E-13 | |
| Reward | 0.443 | (25,277) | 9.15 | 3.8E-24 | 0.342 | (32,376) | 6.75 | 5.2E-22 | |
| Intake | 0.439 | (25,275) | 8.95 | 1.4E-23 | 0.297 | (32,374) | 5.65 | 9.8E-18 | |
| FR5, 0.05mg, 4h | Active Lick | 0.298 | (25,276) | 5.31 | 4.2E-13 | 0.469 | (32,374) | 10.82 | 1.9E-36 |
| Inactive Lick | 0.156 | (25,276) | 2.84 | 1.6E-05 | 0.228 | (32,358) | 4.11 | 1.5E-11 | |
| Reward | 0.655 | (25,278) | 20.38 | 5.2E-49 | 0.417 | (32,374) | 8.95 | 4.5E-30 | |
| Intake | 0.652 | (25,278) | 20.12 | 1.6E-48 | 0.406 | (32,374) | 8.59 | 9.0E-29 | |
| FR5, 0.1mg, 4h | Active Lick | 0.295 | (25,277) | 5.23 | 7.0E-13 | 0.531 | (32,372) | 13.40 | 1.7E-44 |
| Inactive Lick | 0.072 | (25,275) | 1.78 | 1.4E-02 | 0.158 | (32,363) | 2.96 | 4.5E-07 | |
| Reward | 0.663 | (25,277) | 20.93 | 6.3E-50 | 0.378 | (32,372) | 7.65 | 2.5E-25 | |
| Intake | 0.654 | (25,277) | 20.17 | 1.5E-48 | 0.367 | (32,372) | 7.36 | 2.8E-24 | |
| FR5, 0.1mg, 4h Stable | Active Lick | 0.39 | (25,506) | 10.17 | 2.9E-31 | 0.509 | (32,620) | 15.33 | 4.4E-59 |
| Inactive Lick | 0.206 | (25,505) | 4.65 | 4.2E-12 | 0.252 | (32,615) | 5.53 | 7.9E-19 | |
| Reward | 0.644 | (25,506) | 26.86 | 1.1E-76 | 0.369 | (32,620) | 9.10 | 1.5E-34 | |
| Intake | 0.633 | (25,506) | 25.74 | 3.8E-74 | 0.383 | (32,620) | 9.59 | 1.3E-36 | |
| FR5, 0.1mg, 16h | Active Lick | 0.25 | (22,352) | 5.60 | 2.0E-13 | 0.396 | (25,426) | 10.92 | 2.1E-32 |
| Inactive Lick | 0.149 | (22,350) | 3.41 | 7.0E-07 | 0.122 | (25,425) | 3.10 | 1.4E-06 | |
| Reward | 0.252 | (22,352) | 5.65 | 1.4E-13 | 0.292 | (25,426) | 7.25 | 1.0E-20 | |
| Intake | 0.222 | (22,352) | 4.94 | 1.9E-11 | 0.299 | (25,426) | 7.44 | 2.3E-21 | |
| Progressvie Ratio | Active Lick | 0.147 | (23,103) | 1.82 | 2.2E-02 | 0.458 | (29,145) | 5.42 | 2.7E-12 |
| Inactive Lick | 0.083 | (23,101) | 1.41 | 1.2E-01 | 0.212 | (29,145) | 2.41 | 3.4E-04 | |
| BreakPoint | 0.256 | (23,103) | 2.64 | 4.6E-04 | 0.44 | (29,145) | 5.10 | 1.7E-11 | |
| Intake | 0.311 | (23,103) | 3.14 | 3.8E-05 | 0.408 | (29,145) | 4.60 | 3.6E-10 | |
| Extinction Day1 | Active Lick | 0.316 | (21,99) | 3.24 | 4.4E-05 | 0.299 | (25,125) | 3.20 | 1.0E-05 |
| Inactive Lick | 0.142 | (21,99) | 1.80 | 2.9E-02 | 0.106 | (25,125) | 1.61 | 4.6E-02 | |
| Extinction Last Day | Active Lick | 0.22 | (20,81) | 2.26 | 5.4E-03 | 0.275 | (25,127) | 2.95 | 3.9E-05 |
| Inactive Lick | 0.036 | (20,81) | 1.17 | 3.1E-01 | 0.221 | (25,127) | 2.46 | 5.9E-04 | |
| Reinstatement | Active Lick | 0.341 | (21,92) | 3.41 | 2.5E-05 | 0.273 | (27,140) | 2.94 | 2.0E-05 |
| Inactive Lick | 0.07 | (21,92) | 1.35 | 1.7E-01 | 0.255 | (27,140) | 2.76 | 5.9E-05 | |
| Total | Active Lick | 0.217 | (25,2395) | 22.84 | 7.3E-93 | 0.305 | (32,3097) | 37.86 | 3.0E-195 |
| Inactive Lick | 0.122 | (25,2380) | 11.63 | 4.5E-44 | 0.142 | (32,3047) | 14.40 | 2.0E-71 | |
| Reward | 0.326 | (25,2397) | 39.14 | 8.6E-158 | 0.181 | (32,3097) | 19.50 | 5.1E-100 | |
| Intake | 0.196 | (25,2386) | 20.14 | 2.4E-81 | 0.146 | (32,3077) | 15.21 | 4.8E-76 | |