Table 4.
Cox regression analysis of clinical and body composition variables for overall survival.
| Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|
| Variable Category | HR (95% CI) | p-Value | HR (95% CI) | p-Value |
| Age (continuous) |
0.97 (0.93–1.00) |
0.0728 | ||
| Sex Female vs. male (ref) |
1.03 (0.37–2.42) |
0.953 | ||
| ECOG PS 2 vs. 0–1 (ref) |
1.84 (0.82–4.05) |
0.136 | ||
| IMDC risk Poor vs. intermediate (ref) |
3.37 (1.52–7.80) |
0.0029 * | 3.30 (1.48–7.76) |
0.0037 * |
| Liver metastases Yes vs. no (ref) |
2.35 (0.68–6.27) |
0.158 | ||
| NLR (continuous) |
1.18 (1.05–1.30) |
0.0058 * | ||
| PLR (continuous) |
1.002 (0.99–1.004) |
0.0527 | ||
| BMI Overweight vs. normal (ref) |
1.65 (0.68–3.38) |
0.254 | ||
| SFI Low vs. high (ref) |
1.05 (0.47–2.30) |
0.899 | ||
| VFI Low vs. high (ref) |
1.20 (0.55–2.65) |
0.636 | ||
| TFI Low vs. high (ref) |
1.04 (0.48–2.30) |
0.919 | ||
| Sarcopenia Yes vs. no (ref) |
5.45 (1.86–23.2) |
0.0010 * | 5.44 (1.83–23.4) |
0.0013 * |
SFI, VFI, and TFI were categorized as high or low based on sex-specific median values as cut-offs. Asterisk (*) indicates statistical significance. Abbreviations: ECOG, Eastern Cooperative Oncology Group; IMDC, International Metastatic RCC Database Consortium; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; BMI, body mass index; SFI, subcutaneous fat index; VFI, visceral fat index; TFI, total fat index.