Table 2.
Crude and overlap propensity score-weighted odds ratios of gout for colorectal cancer and subgroup analyses according to age, sex, income, region of residence, and CCI scores.
| Characteristics | N of CRC | N of Control | Odd Ratios for CRC (95% Confidence Interval) |
||||
|---|---|---|---|---|---|---|---|
| (Exposure/Total, %) | (Exposure/Total, %) | Crude | p-Value | Overlap-Weighted Model † |
p-Value | ||
| Total participants (n = 49,600) | |||||||
| Gout | 339/9920 (3.4) | 1396/39,680 (3.5) | 0.97 (0.86–1.10) | 0.628 | 0.95 (0.86–1.04) | 0.282 | |
| Control | 9581/9920 (96.6) | 38,284/39,680 (96.5) | 1 | 1 | |||
| Age < 65 years (n = 24,265) | |||||||
| Gout | 127/4853 (2.6) | 590/19,412 (3.0) | 0.86 (0.71–1.04) | 0.12 | 0.82 (0.70–0.95) | 0.009 * | |
| Control | 4726/4853 (97.4) | 18,822/19,412 (97.0) | 1 | 1 | |||
| Age ≥ 65 years (n = 25,335) | |||||||
| Gout | 212/5067 (4.2) | 806/20,268 (4.0) | 1.06 (0.90–1.23) | 0.495 | 1.05 (0.93–1.19) | 0.457 | |
| Control | 4855/5067 (95.8) | 19,462/20,268 (96.0) | 1 | 1 | |||
| Male (n = 29,665) | |||||||
| Gout | 296/5933 (5.0) | 1200/23,732 (5.1) | 0.99 (0.87–1.12) | 0.833 | 0.96 (0.87–1.07) | 0.496 | |
| Control | 5637/5933 (95.0) | 22,532/23,732 (94.9) | 1 | 1 | |||
| Female (n = 19,935) | |||||||
| Gout | 43/3987 (1.1) | 196/15,948 (1.2) | 0.88 (0.63–1.22) | 0.435 | 0.85 (0.66–1.10) | 0.223 | |
| Control | 3944/3987 (98.9) | 15,752/15,948 (98.8) | 1 | 1 | |||
| Low income group (n = 24,025) | |||||||
| Gout | 169/4805 (3.5) | 663/19,220 (3.4) | 1.02 (0.86–1.21) | 0.818 | 0.98 (0.86–1.13) | 0.818 | |
| Control | 4636/4805 (96.5) | 18,557/19,220 (96.6) | 1 | 1 | |||
| High income group (n = 25,575) | |||||||
| Gout | 170/5115 (3.3) | 733/20,460 (3.6) | 0.93 (0.78–1.10) | 0.369 | 0.91 (0.80–1.05) | 0.192 | |
| Control | 4945/5115 (96.7) | 19,727/20,460 (96.4) | 1 | 1 | |||
| Urban resident (n = 22,235) | |||||||
| Gout | 140/4447 (3.1) | 619/17,788 (3.5) | 0.90 (0.75–1.09) | 0.276 | 0.88 (0.76–1.02) | 0.097 | |
| Control | 4307/4447 (96.9) | 17,169/17,788 (96.5) | 1 | 1 | |||
| Rural resident (n = 27,365) | |||||||
| Gout | 199/5473 (3.6) | 777/21,892 (3.5) | 1.03 (0.88–1.20) | 0.755 | 1.00 (0.88–1.14) | 0.975 | |
| Control | 5274/5473 (96.4) | 21,115/21,892 (96.5) | 1 | 1 | |||
| CCI scores = 0 (n = 30,566) | |||||||
| Gout | 164/5448 (3.0) | 737/25,118 (2.9) | 1.03 (0.86–1.22) | 0.761 | 1.02 (0.90–1.17) | 0.728 | |
| Control | 5284/5448 (97.0) | 24,381/25,118 (97.1) | 1 | 1 | |||
| CCI scores = 1 (n = 10,518) | |||||||
| Gout | 74/2600 (2.8) | 286/7918 (3.6) | 0.78 (0.60–1.01) | 0.063 | 0.81 (0.65–1.01) | 0.065 | |
| Control | 2526/2600 (97.2) | 7632/7918 (96.4) | 1 | 1 | |||
| CCI scores ≥ 2 (n = 8516) | |||||||
| Gout | 101/1872 (5.4) | 373/6644 (5.6) | 0.96 (0.77–1.20) | 0.718 | 0.96 (0.79–1.15) | 0.639 | |
| Control | 1771/1872 (94.6) | 6271/6644 (94.4) | 1 | 1 | |||
Abbreviation: CRC, colorectal cancer; CCI, Charlson Comorbidity Index. * Significance at p < 0.05. † Adjusted for age, sex, income, region of residence, and CCI scores.