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[Preprint]. 2023 Dec 1:2023.11.30.569428. [Version 1] doi: 10.1101/2023.11.30.569428

Figure 2 – Neuromuscular Phenotyping in 4mo and 6mo aged mice.

Figure 2 –

A) Bar plot of wire-hang duration of 4mo old mice. Each point represents the average duration of 3 consecutive trials. C3-PMP22 mice have significantly reduced wire-hang duration (p=0.0007) compared to littermate wild-type mice. B) Bar plot of bodyweight of 4mo old mice. Each datapoint indicates one mouse. No significant differences are detected between genotype. C) Bar plot of sciatic nerve conduction velocity of 4mo old mice. Each data point represents one nerve conduction velocity measurement. Significant differences are detected between wild type and C3-PMP22 (p<0.0001), wild type and C3-PMP22::Sipa1l2+/− (p<0.0001), wild type and C3-PMP22::Sipa1l2−/− (p=0.0003). D) Bar plot of wire-hang duration of 6mo old mice. Each datapoint represents the average duration of three consecutive trials. C3-PMP22 and C3-PMP22::Sipa1l2+/− mice have significantly reduced wire-hang duration (p=0.0076 and p=0.0086, respectively) compared to wild-type littermates. E) Bar plot of bodyweight of 6mo mice. Each data point represents one mouse. Only C3-PMP22::Sipa1l2−/− mice differed significantly from wild types (p=0.012). F) Bar plot of sciatic nerve conduction velocity of 6mo old mice. Each datapoint presents one nerve conduction velocity measurement. Significant differences were detected between wildtype mice and C3-PMP22, C3-PMP22::Sipa1l2+/−, and C3-PMP22::Sipa1l2−/− (all p<0.0001). All comparisons are two-way ANOVA with either Tukey’s multiple comparisons test (wire-hang duration, nerve conduction velocity) or Dunnett’s multiple comparisons test (bodyweight). Error bars depict standard deviation.