Figure 4: Performance of DomainFit at different numbers of initial search placements and resolutions.

(A) −log10 of the average p-value at increasing initial search placements for a correct and an unrelated domain. Standard deviations are shown in coloured regions. (B) Appearance changes of a density filtering at 4, 6, 8 and 10 Å resolution. (C) p-value rank of the correct domains fitted to different densities of MIPs at 4, 6, 8, and 10 Å resolution. (D) Number of fitting solutions versus number of initial search placements for maps at 4 Å (blue), 6 Å (red), 8 Å (green) and 10 Å (yellow) resolution. (E) A histogram of the z-transformed correlation score of a correct domain fitted to a density at 4 Å resolution shows a clear separation between the top hit and the rest of the fitting solutions. (F) Histograms of z-transformed correlation score of the same domain fitted to the densities filtered at 6, 8 and 10 Å resolutions. There are significantly fewer fitting solutions at lower resolutions and the separation of the top hit, and the rest is reduced.