Table A3.

The fitted shell size $\kappa$ of the RS model can be mapped to different neighborhood environments of a cell-based model when transferring the parameter to achieve a similar simulation. If two neighborhood condition are shown, e.g., 1-von Neumann/1-Moore, one is chosen randomly for each successive proliferation event. Note that the 3D cellular automaton itself can have variances for the radius $R_{\mathrm{spheroid}}$ that influence the $\kappa$ fitting. Therefore, we used the mean of five 3D cellular automaton simulations to reduce this error.

Neighborhood (ca3d)	Shell Size $\mathit{\kappa }$
1-von Neumann	$0.81$
1-von Neumann/1-Moore	$1.11$
1-Moore	$1.39$
2-von Neumann	$1.48$
2-von Neumann/2-Moore	$2.08$
3-von Neumann	$2.11$
3-von Neumann/2-Moore	$2.42$
2-Moore	$2.58$
3-von Neumann/3-Moore	$2.94$
3-Moore	$3.71$
3-Moore/4-Moore	$4.26$
4-Moore	$4.76$