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. 2023 Nov 28;15(23):5626. doi: 10.3390/cancers15235626

Figure 3.

Figure 3

Systemic mastocytosis with an associated myelodysplastic syndrome with increased blasts-1 (SM-MDS-IB-1). (A,B) One of multiple MC aggregates (A, 100×; B, 400×). (C) Aspirate smear (Wright–Giemsa stain) shows erythroid dysplasia with nuclear budding and irregularity (black arrows) and increased blasts (red arrows). Immunohistochemistry (100×) shows MC aggregates to be positive for: CD117 (D), mast cell tryptase (E), CD25 (F), and CD30 (G). CD61 immunostaining highlights dysplastic megakaryocytes (H), and CD34 immunostaining highlights ~5% blasts (I).