Table:

Platelet activation determined by P-selectin positive or integrin αIIbβ3 activation using flow cytometry.

	PAR4-AP (AYPGKF)(μM)		Thrombin (nM)
	αIIbβ3 activation	P-Selectin	αIIbβ3 activation	P-Selectin
PAR4-P/P	141 (125–160)	184 (156 - nd)	1.2	1.4 (1.3 - nd)
PAR4-P/L	300 (267–335)	380 (347 - nd)	1.0 (0.95–1.2)	1.1 (1.0–1.3)
PAR4-L/L	~ 8900	~ 1544	1.7 (1.3 – 2.1)	1.8 (1.4 – 2.2)

Data are presented as EC50 with a ± 95% confidence interval. Undefined confidence intervals are indicated as nd. The maximum response of PAR4-L/L to AYPGKF is greater than 1600 μM; EC50 values are estimated.