Table 3.
Li response genes nominally associated with psychiatric symptoms/PGSs for comorbid conditions in ConLiGen. Shown are the overlapping and non-overlapping genes between BP-I and BP-II diagnostic groups.
| Phenotype | BP-I only | BP-II only | Overlap |
|---|---|---|---|
| # Manic episodes | ADGRD1, FANK1, FGD4, SLC13A3, SLC9C2 | ALPK1, CSMD2, ELOVL6, GRIN2A, TTC39B | CRYBB3, DNAH14, RNLS, TNRC6C, ZBTB2 |
| # Depressive episodes | ADGRD1, CDK3, MTSS1, RGCC, S100A11, TTC39B, TYSND1 | ELOVL6, RBM47, SLC13A3, TMEM196, ZBTB2 | ALPK1, CSMD2, DNAH14, FGD4, GRIN2A, RNLS |
| Alcohol abuse | ADGRD1, CRYBB3, CSMD2, DNAH14, ELOVL6, RNLS, SLC9C2 | ALPK1, FGD4, TNRC6C | GRIN2A, TTC39B |
| Substance abuse | ADGRD1, CSMD2, MTSS1, RNLS, TTC39B | - | - |
| Psychosis | ALPK1, FGD4, GRIN2A, MTSS1, TMEM196, TNRC6C, ZFP28 | ADGRD1, RBM47, TMEM131, TTC39B | CSMD2, DNAH14, ELOVL6 |
| Suicidal ideation | ADGRD1, CSMD2, DNAH14, GRIN2A, MTSS1 | FGD4, MTSS1, RBM47, SLC9C2, TTC39B, TYSND1 | RNLS |
| Insomnia PGS | ALPK1, CSMD2, TTC39B | ADGRD1, GRIN2A, OR2AP1, TMEM131 | DNAH14, MTSS1, RNLS |
| Sleep duration PGS | ELOVL6, FANK1, GRIN2A, RNLS, SLC9C2 | FGD4, RBM47, TMEM98 | ADGRD1, ALPK1, CRYBB3, CSMD2, DNAH14, TTC39B |
| Chronotype PGS | ELOVL6, RNLS | CRYBB3, DNAH14, MTSS1, TNRC6C | ALPK1, CSMD2, GRIN2A |
| Diabetes PGS | ADGRD1, FANK1, OR2AP1, SLC9C2, TTC39B | ALPK1, TNRC6C | CSMD2, DNAH14, ELOVL6, FGD4, GRIN2A, MTSS1, RNLS |
| Hypertension PGS |
FANK1, TNRC6C, TRAF4 | ADGRD1, CRYBB3, CSMD2, DNAH14, OCSTAMP, TMEM196 | FGD4, GRIN2A, RNLS, TTC39B |
| Hypothyroidism PGS | GRIN2A, TMEM98, TNRC6C, TTC39B | ALPK1, BMF, TRAF4 | ADGRD1, CSMD2, MTSS1, RNLS |