Table 1.
Summary of statistical analysis
| Figure | Statistical Tests | Comparison | Value | P value | |
|---|---|---|---|---|---|
| Figure 1 | B | Mann-Whitney test | Air vs EtOH | U = 0 | P < 0.0001 |
| C | Mann-Whitney test | Air vs EtOH | U = 9 | P = 0.0011 | |
| D | Mann-Whitney test | Air vs EtOH | U = 1 | P < 0.0001 | |
| E | Mann-Whitney test | Air vs EtOH | U = 4 | P = 0.0001 | |
| F | Mann-Whitney test | Air vs EtOH | U = 1.5 | P < 0.0001 | |
| G | Mann-Whitney test | Air vs EtOH | U = 4 | P = 0.0001 | |
| H | Mann-Whitney test | Air vs EtOH | U = 37 | P = 0.3423 | |
| I | Correlation | ApolipoproteinE vs LDL-C | R = 0.6897 | P = 0.0008 | |
| J | Mann-Whitney test | Air vs EtOH | U = 13 | P = 0.0039 | |
| K | Mann-Whitney test | Air vs EtOH | U = 18 | P = 0.0138 | |
| L | Mann-Whitney test | Air vs EtOH | U = 47 | P = 0.8534 | |
| M | Correlation | ApolipoproteinE vs LDL-C | R = 0.5964 | P = 0.0021 | |
| Figure 2 | C (LRP1) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 |
| C (p-IKK-α/β) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| C (t-IKK-α/β) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| C (p-/t-IKK-α/β) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.0317 | |
| C (IκB-α) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| C (NF-κB) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| D (LRP1) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| D (p-IKK-α/β) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| D (t-IKK-α/β) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| D (p-/t-IKK-α/β) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| D (IκB-α) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.0317 | |
| D (NF-κB) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| Figure 3 | A (Total, IL-1β, Cortex) | Mann-Whitney test | Air vs EtOH | U = 10 | P = 0.0014 |
| A (Total, IL-1β, Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 9.5 | P = 0.0011 | |
| A (Total, TNF-α, Cortex) | Mann-Whitney test | Air vs EtOH | U = 18 | P = 0.0147 | |
| A (Total, TNF-α Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 12 | P = 0.0018 | |
| B (Male, IL-1β, Cortex) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| B (Male, IL-1β, Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| B (Male, TNF-α Cortex) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.317 | |
| B (Male, TNF-α Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| C (Female, IL-1β, Cortex) | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.3905 | |
| C (Female, IL-1β, Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 9 | P = 0.5476 | |
| C (Female, TNF-α Cortex) | Mann-Whitney test | Air vs EtOH | U = 6 | P = 0.2222 | |
| C (Female, TNF-α Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 5 | P = 0.1508 | |
| Figure 4 | B | Mann-Whitney test | Air vs EtOH | U = 13 | P = 0.0038 |
| C | Mann-Whitney test | Air vs EtOH | U = 3.5 | P < 0.0001 | |
| Figure 5 | A | Mann-Whitney test | Air vs EtOH | U = 56 | P = 0.3698 |
| B | Mann-Whitney test | Air vs EtOH | U = 0 | P < 0.0001 | |
| C | Mann-Whitney test | Air vs EtOH | U = 23 | P = 0.0036 | |
| D | Mann-Whitney test | Air vs EtOH | U = 50 | P = 0.2133 | |
| E | Mann-Whitney test | Air vs EtOH | U = 10 | P = 0.0001 | |
| F | Mann-Whitney test | Air vs EtOH | U = 29 | P = 0.0121 | |
| Figure 6 | B | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.0005 |
| C | Mann-Whitney test | Air vs EtOH | U = 0 | P < 0.0001 | |
| Figure 7 | B | Mann-Whitney test | Air vs EtOH | U = 116.5 | P < 0.0001 |
| C | Mann-Whitney test | Air vs EtOH | U = 359.5 | P = 0.9623 | |
| E (Air) | Mann-Whitney test | Air vs EtOH | U = 256 | P = 0.8618 | |
| FD (EtOH) | Mann-Whitney test | Air vs EtOH | U = 108 | P < 0.0001 | |
| H | Two-way ANOVA | Air vs EtOH | F (3, 88) = 5.433 | P = 0.0018 | |
| I | Two-way ANOVA | (PF) Air vs (PF) EtOH | F (3, 88) = 6.786 | P = 0.0138 | |
| J | Two-way ANOVA | Air vs EtOH | F (3, 88) = 9.313 | P < 0.0001 | |
| Sup Fig.1 | C (Male, Presymptomatic, Body weight) | Two-way ANOVA | Air vs EtOH | F (4, 62) = 0.3201 | P = 0.8635 |
| C (Female, Symptomatic, Body weight) | Two-way ANOVA | Air vs EtOH | F (4, 100) = 0.8585 | P = 0.4917 | |
| D (Male, Presymptomatic, Body weight) | Two-way ANOVA | Air vs EtOH | F (3, 32) = 0.3373 | P = 0.7984 | |
| D (Female, Symptomatic, Body weight) | Two-way ANOVA | Air vs EtOH | F (3, 31) = 0.6150 | P = 0.6105 | |
| Sup Fig.3 | A (ApoE, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 |
| A (ApoE, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 1 | P = 0.0159 | |
| A (ApoE, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| A (ApoE, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.0317 | |
| B (GFAP, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 1 | P = 0.0159 | |
| B (GFAP, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| B (GFAP, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| B (GFAP, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| C (ApoE, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 1.5 | P = 0.0238 | |
| C (ApoE, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| C (ApoE, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 3 | P = 0.0478 | |
| C (ApoE, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 3 | P = 0.0456 | |
| Sup Fig.4 | A | Mann-Whitney test | Air vs EtOH | U = 40.5 | P = 0.4926 |
| B | Mann-Whitney test | Air vs EtOH | U = 37 | P = 0.3423 | |
| C | Mann-Whitney test | Air vs EtOH | U = 26 | P = 0.0753 | |
| D | Mann-Whitney test | Air vs EtOH | U = 9 | P = 0.0011 | |
| E | Mann-Whitney test | Air vs EtOH | U = 31 | P = 0.1649 | |
| F | Mann-Whitney test | Air vs EtOH | U = 47 | P = 0.8534 | |
| G | Mann-Whitney test | Air vs EtOH | U = 38 | P = 0.3930 | |
| H | Mann-Whitney test | Air vs EtOH | U = 10 | P = 0.0278 | |
| Sup Fig.5 | A (HDL-C, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.3095 |
| A (HDL-C, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 8.5 | P = 0.4603 | |
| A (HDL-C, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 12.5 | P > 0.9999 | |
| A (HDL-C, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.3095 | |
| B (LDL-C, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 1 | P = 0.0159 | |
| B (LDL-C, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 1 | P = 0.0159 | |
| B (LDL-C, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 2.5 | P = 0.0397 | |
| B (LDL-C, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.0317 | |
| C (Total-C, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.3095 | |
| C (Total-C, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 12 | P > 0.9999 | |
| C (Total-C, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 11 | P = 0.8413 | |
| C (Total-C, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 9 | P = 0.5476 | |
| Sup Fig.6 | A | One-way ANOVA | Air vs EtOH (Male) | F (3, 9) = 1.031 | P = 0.9636 |
| Air vs EtOH (Female) | P = 0.5892 | ||||
| B | One-way ANOVA | Air vs EtOH (Male) | F (3, 9) = 0.9527 | P = 0.7369 | |
| Air vs EtOH (Female) | P = 0.5858 | ||||
| C | One-way ANOVA | Air vs EtOH (Male) | F (3, 11) = 8.388 | P = 0.0209 | |
| Air vs EtOH (Female) | P = 0.4809 | ||||
| D | One-way ANOVA | Air vs EtOH (Male) | F (3, 10) = 0.6277 | P = 0.8978 | |
| Air vs EtOH (Female) | P = 0.9988 | ||||
| E | One-way ANOVA | Air vs EtOH (Male) | F (3, 11) = 12.16 | P = 0.9998 | |
| Air vs EtOH (Female) | P = 0.0015 | ||||
| F | One-way ANOVA | Air vs EtOH (Male) | F (3, 10) = 1.222 | P = 0.9984 | |
| Air vs EtOH (Female) | P = 0.7469 | ||||
| G | One-way ANOVA | Air vs EtOH (Male) | F (3, 12) = 0.7291 | P = 0.9994 | |
| Air vs EtOH (Female) | P = 0.0454 | ||||
| H | One-way ANOVA | Air vs EtOH (Male) | F (3, 9) = 1.290 | P = 0.9815 | |
| Air vs EtOH (Female) | P = 0.4227 | ||||
| I | One-way ANOVA | Air vs EtOH (Male) | F (3, 12) = 1.549 | P = 0.2216 | |
| Air vs EtOH (Female) | P = 0.9233 | ||||
| J | One-way ANOVA | Air vs EtOH (Male) | F (3, 10) = 5.033 | P = 0.0097 | |
| Air vs EtOH (Female) | P = 0.9996 | ||||
| Sup Fig.7 | A | Mann-Whitney test | Air vs EtOH | U = 12 | P > 0.9999 |
| B | Mann-Whitney test | Air vs EtOH | U = 10 | P = 0.6905 | |
| C | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.3095 | |
| D | Mann-Whitney test | Air vs EtOH | U = 1 | P = 0.0159 | |
| Sup Fig.8 | A (Aβ, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.0317 |
| A (Aβ, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 2 | P = 0.0269 | |
| A (Aβ, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 0.5 | P = 0.0159 | |
| A (Aβ, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0079 | |
| B (Aβ40, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 10 | P = 0.2251 | |
| B (Aβ40, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 16 | P = 0.7835 | |
| B (Aβ40, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 15.5 | P = 0.7338 | |
| B (Aβ40, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 7.5 | P = 0.1039 | |
| C (Aβ42, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0022 | |
| C (Aβ42, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0022 | |
| C (Aβ42, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0022 | |
| C (Aβ42, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0022 | |
| Sup Fig.9 | C | Mann-Whitney test | Air vs EtOH | U = 38.5 | P = 0.9136 |
| D | Mann-Whitney test | Air vs EtOH | U = 32 | P = 0.4992 | |
| Sup Fig.10 | A (FDG, Cortex, Male) | Mann-Whitney test | Air vs EtOH | U = 1.5 | P = 0.0203 |
| A (FDG, Cortex, Female) | Mann-Whitney test | Air vs EtOH | U = 3 | P = 0.0303 | |
| A (FDG, Hippocampus, Male) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0001 | |
| A (FDG, Hippocampus, Female) | Mann-Whitney test | Air vs EtOH | U = 3 | P = 0.0401 | |
| Sup Fig.11 | B | Mann-Whitney test | Air vs EtOH | U = 8 | P > 0.9999 |
| C | Mann-Whitney test | Air vs EtOH | U = 7 | P = 0.8857 | |
| Sup Fig.12 | A | Mann-Whitney test | Air vs EtOH | U = 101.5 | P = 0.1414 |
| B | Mann-Whitney test | Air vs EtOH | U = 171.5 | P = 0.8003 | |
| C | Mann-Whitney test | Air vs EtOH | U = 110 | P = 0.1626 | |
| D | Mann-Whitney test | Air vs EtOH | U = 109 | P = 0.1528 | |
| E | Mann-Whitney test | Air vs EtOH | U = 299 | P = 0.5061 | |
| F | Mann-Whitney test | Air vs EtOH | U = 326 | P = 0.7032 | |
| G | Mann-Whitney test | Air vs EtOH | U = 62 | P = 0.5899 | |
| H | Mann-Whitney test | Air vs EtOH | U = 70 | P = 0.9323 | |
| Sup Fig.13 | A | Mann-Whitney test | Air vs EtOH | U = 122 | P = 0.2112 |
| B | Mann-Whitney test | Air vs EtOH | U = 132 | P = 0.3503 | |
| C | Mann-Whitney test | Air vs EtOH | U = 23 | P < 0.0001 | |
| D | Mann-Whitney test | Air vs EtOH | U = 22 | P < 0.0001 | |
| Sup Fig.14 | A | Mann-Whitney test | Air vs EtOH | U = 26.5 | P = 0.2457 |
| B | Mann-Whitney test | Air vs EtOH | U = 19.5 | P = 0.0706 | |
| C | Mann-Whitney test | Air vs EtOH | U = 20 | P = 0.0831 | |
| D | Mann-Whitney test | Air vs EtOH | U = 40 | P > 0.9999 | |
| E | Mann-Whitney test | Air vs EtOH | U = 28 | P = 0.3154 | |
| F | Mann-Whitney test | Air vs EtOH | U = 38 | P = 0.8968 | |
| G | Mann-Whitney test | Air vs EtOH | U = 26 | P = 0.9546 | |
| H | Mann-Whitney test | Air vs EtOH | U = 17 | P = 0.1806 | |
| 1 | Two-way ANOVA | Air vs EtOH | F (3, 40) = 1.476 | P = 0.2356 | |
| J | Two-way ANOVA | Air vs EtOH | F (3, 88) = 1.716 | P = 0.1694 | |
| K | Two-way ANOVA | Air vs EtOH | F (3, 40) = 1.204 | P = 0.9961 | |
| Sup Fig.15 | A | Mann-Whitney test | Air vs EtOH (Male) | U = 10.5 | P = 0.0004 |
| Air vs EtOH (Female) | U = 56 | P = 0.0113 | |||
| B | Mann-Whitney test | Air vs EtOH (Male) | U = 65.5 | P = 0.9878 | |
| Air vs EtOH (Female) | U = 118 | P = 0.9766 | |||
| C | Mann-Whitney test | Old vs New object (Air male) | U = 45 | P = 0.3653 | |
| Old vs New object (Air female) | U = 47 | P = 0.1600 | |||
| D | Mann-Whitney test | Old vs New object (EtOH male) | U = 15 | P = 0.0019 | |
| Air vs Old vs New object (EtOH female) | U = 42 | P = 0.0027 | |||
| E (Male) | Two-way ANOVA | Air vs EtOH | F (3, 32) = 5.215 | P = 0.0048 | |
| F (Male) | Two-way ANOVA | Air vs EtOH | F (3, 48) = 2.693 | P = 0.0465 | |
| G (Female) | Two-way ANOVA | Air vs EtOH | F (3, 32) = 6.761 | P = 0.0012 | |
| H (Female) | Two-way ANOVA | Air vs EtOH | F (3, 88) = 3.638 | P = 0.0191 | |
| Sup Fig.16 | A (ALT, Cortex) | Mann-Whitney test | Air vs EtOH | U = 8 | P = 0.1320 |
| A (ALT, Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 14 | P = 0.5887 | |
| A (ALT, Liver) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0022 | |
| B (AST, Cortex) | Mann-Whitney test | Air vs EtOH | U = 16 | P = 0.8182 | |
| B (AST, Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 8.5 | P = 0.1450 | |
| B (AST, Liver) | Mann-Whitney test | Air vs EtOH | U = 15 | P = 0.6623 | |
| C (ALT/AST, Cortex) | Mann-Whitney test | Air vs EtOH | U = 12 | P = 0.3939 | |
| C (ALT/AST, Hippocampus) | Mann-Whitney test | Air vs EtOH | U = 11 | P = 0.3095 | |
| C (ALT/AST, Liver) | Mann-Whitney test | Air vs EtOH | U = 0 | P = 0.0022 |