Figure 3.

Model validation with preclinical and clinical data. Microbiome modulation was assumed to affect only the parameters $K_{rc}$ and $A_{rc}$. Comparison of model predictions with measured. A) Schematic of followed procedure (Created with BioRender.com) B) Experimental details for each experiment C) clinical data that include 9 patients (Baruch et al. ¹⁶) and D) preclinical tumor volume data that include 62 mice which received only FMT modulation of microbiome (Spencer et al. ¹⁷ and an unpublished FMT data set). E) Range of $K_{rc}$ and $A_{rc}$ parameters employed for the results in figure 3D, blue and red points correspond to responders and non-responders, respectively.