Figure 2.

Role of NBCe1 in ischemia-induced changes in astrocytic pH_i and [Na⁺]_i. Data are presented the same as in Figure 1. (a) Change in pH_i evoked by chemical ischemia for 2 min in control and with addition of S0859. (b) Change in [Na⁺]_i evoked by chemical ischemia in control (Ctrl) and with addition of S0859. (c) Change in pH_i evoked by chemical ischemia for 2 min in slices derived from wild-type mice (WT) and from NBCe1 KO. (d) Left: Change in [Na⁺]_i in wild-type and NBCe1 KO. Periods of chemical ischemia are indicated with the light-red areas; downward traces represent acidification. Dashed lines indicate baseline levels. Box plots on the right summarize the results from these experiments and show individual data points (dots), means (squares), interquartile ranges (boxes), medians (lines), and SD (whiskers). *** p < 0.001.