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. 2023 Nov 22;24(23):16628. doi: 10.3390/ijms242316628

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Summary of the statistically calculated direction (excitation/attenuation) neuronal responses of VTA, LC, and DR neurons recorded from animals that exhibited behavioral tolerance after chronic MPD exposure. Each bar represents a percentage of the neuronal responses within each brain region that responded to each respective MPD dose. A positive percentage represents the proportion of neurons within a brain region that exhibited a significant (p < 0.05) increase in neuronal activity. A negative percentage represents the proportion of neurons within a brain region that exhibited a significant (p < 0.05) decrease in neuronal activity. Top panel: comparison of VTA, LC, and DR responses after acute MPD exposure (ED1 MPD/ED1 BL). Middle panel: comparison of VTA, LC, and DR responses at baseline (ED10 BL/ED1 BL). Bottom panel: comparison of VTA, LC, and DR responses after chronic MPD exposure (ED10 MPD/ED1 MPD).