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. 2023 Nov 27;12(23):2718. doi: 10.3390/cells12232718

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Origins of small hepatocytes in GalN-treated rat livers. (A) SHs are derived from OCs and MHs. GalN administration activates portal Thy1⁺ cells and the Canal of Hering to induce OCs, and then OCs differentiate into SHs and BECs within 3 days after the treatment. Conversely, the slightly damaged MHs are delayed to start their proliferation, and MH-SHs are derived from MHs. Some OC-SHs and the proliferated MH-SHs are differentiated into MHs. (B) Typical markers of the specific cell appeared in the process of liver regeneration by GalN administration.