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The emergence of small hepatocyte-like progenitor cells (SHPCs) in Ret/PH rat livers. Ret is intraperitoneally injected into rats at 2-week intervals, and 2/3 PH is performed 4 weeks after the second injection. SHPCs proliferate to form clusters, and SHPCs gradually differentiate into MHs 30 days later, and the liver mass is recovered. Thereafter, the number of replicative senescent hepatocytes increases. BD, bile duct; CV, central vein.
