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The signal transduction of TGF-β2. In cells with TβR3 receptors, active TGF-β2 firstly binds to TβR3 and then recruits TβR2 and TβR1. Finally, TβR3 is dissociated from the above complex and eventually forms the TGF-β2/TβR1/TβR2 complex. Intracellular signalling is mediated by both canonical and non-canonical signalling pathways that regulate the expression of target genes.
