. 2023 Nov 22;24(23):16610. doi: 10.3390/ijms242316610

Table 4.

Canonical correlation analysis between cases and controls with septic shock pretreatment.

Variable	Level	Variable	Coef.	Std. Err.	t	p-Value	IC95%		Corr.
u1	High	PCT	0.0172182	0.0042318	4.07	0.0001	0.0085873	0.0258491	0.9529
	High	Carbonyl	−0.0068545	0.0030781	−2.23	0.033	−0.0131324	−0.0005766
	Low	TAC	−0.0002907	0.0000967	−3.01	0.005	−0.000488	−0.0000935
		GSH	5.295229	1.522535	3.48	0.002	2.189998	8.400459
		Vit C	6.144225	0.6809717	9.02	0.001	4.755374	7.533075
v1	Low	IL4	−0.0073968	0.0025368	−2.92	0.007	−0.0125706	−0.002223
	High	IP10	0.0009865	0.0001994	4.95	0.001	0.0005798	0.0013932
		IL1B	0.0002558	0.000123	2.08	0.046	5.01 × 10⁻⁶	0.0005067
		MCP 1	−0.0006084	0.0001506	−4.04	0.001	−0.0009155	−0.0003012
		IL6	0.0003399	0.0000436	7.8	0.001	0.0002511	0.0004288
		ILl17a	−0.0098983	0.0025994	−3.81	0.001	−0.0151998	−0.0045967
		TNFα	0.049159	0.0144382	3.4	0.002	0.0197122	0.0786059
u2	High	LPO	−0.1764843	0.0744333	−2.37	0.024	−0.328292	−0.0246766	0.8643
	High	Carbonyl	0.0164766	0.0056307	2.93	0.006	0.0049928	0.0279604
	Low	GSH	−11.67688	2.785091	−4.19	0.001	−17.35711	−5.996647
		Selenium	492.1174	139.0012	3.54	0.001	208.6226	775.6122
		Thiol	−0.1522415	0.0385513	−3.95	0.001	−0.2308675	−0.0736155
v2	Low	il4	0.0124842	0.0046404	2.69	0.011	0.00302	0.0219484
		IL12p70	0.0367106	0.0155704	2.36	0.025	0.0049544	0.0684667
		IFNy	−0.0140323	0.0035662	−3.93	0.001	−0.0213055	−0.006759
		TGFB1	0.0031482	0.00154	2.04	0.049	7.40 × 10⁻⁶	0.006289
	High	IL1B	−0.0007156	0.000225	−3.18	0.003	−0.0011744	−0.0002568
		MCP1	0.0013014	0.0002755	4.72	0.001	0.0007396	0.0018632
		IL6a	0.0002323	0.0000797	2.92	0.007	0.0000698	0.0003947
u3	High	SOFA	−0.3846204	0.1060993	−3.63	0.001	−0.6010113	−0.1682295	0.8218
		PCT	−0.0219292	0.009223	−2.38	0.024	−0.0407397	−0.0031188
		PCR	0.0441247	0.0167844	2.63	0.013	0.0098926	0.0783568
	Low	GSH	6.547262	3.318249	1.97	0.057	−0.2203513	13.31488
	Low	GSHpx	−6.29239	1.747836	−3.6	0.001	−9.857125	−2.727655
v3	Low	IL4	0.0070789	0.0055288	1.28	0.21	−0.004197	0.0183549
		TGFB1	0.0038936	0.0018348	2.12	0.042	0.0001515	0.0076356
		IL12p70	−0.0400625	0.0185511	−2.16	0.039	−0.0778978	−0.0022272
	High	IL1B	−0.0007372	0.000268	−2.75	0.01	−0.0012838	−0.0001905
	High	IL8	0.0300677	0.0085392	3.52	0.001	0.0126518	0.0474836

The canonical correlation revealed a significantly high correlation between the first (0.9529), the second (0.8643), and third (0.8218). Lambda test with an F = 0.001; the Lawley–Hotteling trace and Loy’s largest root yielded the same statistical significance.