Table A2.
Multivariate generalized linear regression analysis of predictors of high molecular weight (HMWP) metabolites (ng/mL).
| Predictors | HMWP Metabolites | ||
|---|---|---|---|
| MCPP | MECPP | MEHHP | |
| Adjusted Model | Estimate (95% Cl) | ||
| Age (years) | |||
| <20 | REF | ||
| 20–34 | −0.27 (−1.81, 1.26) | 1.30 (−2.99, 5.60) | 1.06 (−6.33, 8.46) |
| ≥35 | −0.15 (−2.18, 1.87) | −1.31 (−6.98, 4.37) | −3.00 (−12.78, 6.78) |
| p-value | 0.93 | 0.34 | 0.46 |
| Race/ethnicity | |||
| Non-Hispanic White | REF | ||
| Non-Hispanic Black/African American | −1.73 (−3.07, −0.39) | −2.04 (−5.80, 1.71) | −0.02 (−6.49, 6.45) |
| Hispanic | −0.06 (−1.30, 1.17) | 3.03 (−0.43, 6.50) | 5.20 (−0.76, 11.17) |
| Asian | −1.18 (−2.98, 0.63) | 1.12 (−3.94, 6.19) | −1.34 (−10.06, 7.39) |
|
American Indian, Native Hawaiian other,
or more than 1 race |
−0.89 (−2.95, 1.18) | −2.64 (−8.43, 3.15) | −5.49 (−15.46, 4.48) |
| p-value | 0.07 | 0.14 | 0.26 |
| Education level | |||
| Less than HS grad | REF | ||
| HS grad or GED | −0.91 (−2.74, 0.92) | −2.43 (−7.56, 2.70) | −4.77 (−13.60, 4.07) |
| Some college or Assoc/Tech degree | 0.58 (−1.11, 2.27) | 0.64 (−4.10, 5.37) | 1.64 (−6.52, 9.80) |
| Completed college | 0.63 (−1.21, 2.47) | −2.10 (−7.27, 3.06) | −2.22 (−11.12, 6.67) |
| Degree work beyond college | 1.46 (−0.46, 3.38) | −0.88 (−6.26, 4.50) | 0.90 (−8.36, 10.16) |
| p-value | 0.09 | 0.39 | 0.31 |
| Pre-pregnancy BMI | |||
| Normal 18.5–<25 | REF | ||
| Underweight <18.5 | 0.89 (−0.98, 2.76) | −0.78 (−6.03, 4.47) | −2.68 (−11.73, 6.36) |
| Overweight 25–<30 | 1.02 (0.03, 2.00) | 0.61 (−2.15, 3.36) | 0.21 (−4.54, 4.96) |
| Obese ≥30 | 1.27 (0.18, 2.36) | 2.40 (−0.64, 5.45) | 5.40 (0.15, 10.65) |
| p-value | 0.07 | 0.44 | 0.16 |
| Clinical site | |||
| Case Western Reserve University, OH | REF | ||
| Columbia University, NY | 0.25 (−1.61, 2.10) | 5.26 (0.06, 10.46) | 10.00 (1.04, 18.97) |
| Indiana University, IN | −0.46 (−2.49, 1.58) | 1.53 (−4.16, 7.22) | 2.92 (−6.88, 12.72) |
| Magee-Women’s Hospital, PA | −0.34 (−2.25, 1.57) | −0.53 (−5.89, 4.83) | −2.12 (−11.35, 7.12) |
| Northwestern University, IL | −0.85 (−2.87, 1.18) | 0.03 (−5.64, 5.70) | −0.35 (−10.12, 9.42) |
| University of California Irvine, CA | −2.15 (−4.37, 0.07) | −3.03 (−9.25, 3.18) | −2.63 (−13.34, 8.07) |
| University of Pennsylvania, PA | 2.01 (−0.15, 4.17) | 5.83 (−0.22, 11.89) | 11.70 (1.27, 22.13) |
| University of Utah, UT | −1.39 (−3.27, 0.49) | 2.96 (−2.31, 8.23) | 6.69 (−2.38, 15.77) |
| p-value | 0.00 | 0.00 | 0.00 |