Table 2.

Genetic mutations are identified in the primary electrical diseases [1,4,5,6]. GOF, gain of function; LOF, loss of function.

Protein	Gene	Disease
Na channels	SCN5A	Long QT3 (GOF)
		Brugada syndrome (LOF)
K channels	KCNQ1	Long QT1 (LOF) Short QT2 (GOF)
	KCNH2	Long QT2 (LOF) Short QT1 (GOF)
	KCNJ2	Andersen–Tawil syndrome (LOF) Short QT3 (GOF)
	DPP6/Kv4.x	Idiopathic familial ventricular fibrillation (GOF)
Ca channels	CACNA1C	Brugada syndrome (LOF)
		Timothy syndrome (GOF)
	RYR2	Catecholaminergic polymorphic VT (GOF) Calcium release deficiency syndrome (LOF) Exon 3 deletion syndrome
Regulatory proteins	CASQ2	Catecholaminergic polymorphic VT (LOF)
	CALM	Long QTS (GOF) Catecholaminergic polymorphic VT (LOF) Idiopathic ventricular fibrillation