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. 2023 Nov 24;24(23):16726. doi: 10.3390/ijms242316726

Figure 3.

Figure 3

Main epigenetic changes in suicide behavior. The figure represents the main DNA methylation changes observed in peripheral blood cells and brain areas of patients with suicide behavior and in those who died by suicide, respectively. HPA axis: hypothalamus–pituitary–adrenal axis, NR3C1: gene encoding glucocorticoid receptor, FKBP5: the gene encoding the FK506-binding protein 5, CRHBP: the gene encoding the corticotropin-releasing hormone binding protein, SKA2: gene encoding spindle and kinetochore associated complex subunit 2, BDNF: the gene encoding the brain-derived neurotrophic factor, HTR1A: the gene encoding serotonin receptor 1 A, MAOA: the gene encoding monoamine oxidase A, SCL6A4: serotonin transporter gene, TPH2: gene encoding tryptophan hydroxylase 2, NRTK2: the gene encoding neurotrophic receptor tyrosine kinase 2; GABRA1: the gene encoding the alpha-1 subunit of the GABAA receptor protein.