KSHV |
Kaposi’s sarcoma-associated herpesvirus |
HHV8 |
Human herpesvirus-8 |
EBV |
Epstein–Barr virus |
TRN |
Transcription factor or transcriptional regulatory network |
IEGs |
Immediate-early genes |
TFs |
Transcription factors |
IL-8 |
Interleukin 8 |
CXCL8 |
Chemokine (C-X-C motif) ligand 8 |
CXCL7 |
Chemokine (C-X-C motif) ligand 7 |
CCL19 |
Chemokine (C-C motif) ligand 19 |
CXCL13 |
Chemokine (C-X-C motif) ligand 13 |
MSI |
Microsatellite instability |
MSS |
Microsatellite stability |
APC |
Adenomatous polyposis coli |
KRAS |
Kirsten rat sarcoma virus |
PIK3CA |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
SMAD4 |
Mothers against decapentaplegic homolog 4 |
TP53 |
Tumor protein P53 |
DCC |
Netrin receptor |
SMAD |
Mothers against decapentaplegic |
BRAF |
B-Raf Proto-Oncogene |
Wnt |
Wingless-related integration site |
BMP |
Bone morphogenetic protein |
TGFβ |
Transforming growth factor-beta |
Ras |
Rat sarcoma virus |
ST6GALNAC1 |
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
CDH1 |
Cadherin 1 |
STK11 |
Serine/threonine kinase 11 |
MLH1 |
mutL homolog 1 |
MSH2 |
mutS homolog 2 |
EPCAM |
Epithelial cell adhesion molecule |
MSH6 |
mutS homolog 6 |
PMS2 |
PMS1 homolog 2, mismatch repair system component |
FAP |
Familial adenomatous polyposis |
BRCA2 |
BReast CAncer gene 2 |
PALB2 |
Partner and localizer of BRCA2 |
CLDN18-ARHGAP |
Fusion Gene_Claudin 18-Rho GTPase-activating protein |
ARID1A |
AT-rich interaction domain 1A |
PD-L1/2 |
Programmed cell death ligand ½ |
ICIs |
Immune checkpoint inhibitors |
CTLA-4 |
Cytotoxic T-lymphocyte associated protein 4 |
PD-1 |
Programmed cell death 1 |
LAG-3 |
Lymphocyte activating 3 |
TIM-3 |
Hepatitis A virus cellular receptor 2 |
PD-L1 |
CD274 molecule |
ERBB2 |
erb-b2 receptor tyrosine kinase 2 |
MET |
Methoprene-tolerant proto-oncogene, receptor tyrosine kinase |
NKX2 |
Ventral nervous system defective |
DOK2 |
Docking protein 2 |
ALK |
Anaplastic lymphoma receptor tyrosine kinase |
ROS1 |
ROS proto-oncogene 1, receptor tyrosine kinase |
RET |
Ret proto-oncogene |
ALK/EML4 |
Anaplastic lymphoma receptor tyrosine kinase–Echinoderm microtubule-associated protein-like 4 |
TTN |
titin |
CSMD3 |
CUB and Sushi multiple domains 3 |
MUT16 |
MUTator 16 |
RYR2 |
Ryanodine receptor 2 |
BRINP3 |
BMP/retinoic acid inducible neural specific 3 |
COL11A1 |
Collagen type XI alpha 1 chain |
GRIN2B |
Glutamate ionotropic receptor NMDA type subunit 2B |
MUC5B |
Mucin 5B, oligomeric mucus/gel-forming |
NLRP3 |
NLR family pyrin domain containing 3 |
TENM3 |
Teneurin transmembrane protein 3 |
NSCLC |
Non-small cell lung cancer |
LUAD |
Lung adenocarcinoma |
LUSC |
Lung squamous cell carcinoma |
TCGA-STAD |
The Cancer Genome Atlas Stomach Adenocarcinoma |
RUNX2 |
Runt-related transcription factor 2 |
SOX4 |
SRY-box transcription factor 4 |
SOX17 |
SRY-box transcription factor 17 |
BZW2 |
Basic leucine zipper and W2 domains 2 |
FOXM1 |
Forkhead box M1 |
ZBTB16 |
Zinc finger and BTB domain containing 16 |
TAL1 |
T-cell acute lymphocytic leukemia 1 bHLH transcription factor 1, erythroid differentiation factor |
KLF4 |
Kruppel-like transcription factor 4 |
EPAS1 |
Endothelial PAS domain protein 1 |
HOXC6 |
Homeobox C6 |
ID4 |
Inhibitor of DNA binding 4 |
KLF2 |
Kruppel-like transcription factor 2 |
MEIS1 |
Meis homeobox 1 |
NR2F1 |
Nuclear receptor subfamily 2 group F member 1 |
TBX4 |
T-box transcription factor 4 |
TCF21 |
Transcription factor 21 |
TFAP2C |
Transcription factor AP-2 gamma |
LMO2 |
LIM domain only 2 |
MNDA |
Myeloid cell nuclear differentiation antigen |
FOXF1 |
Forkhead box F1 |
HLF |
HLF transcription factor, PAR bZIP family member |
RFX2 |
Regulatory factor X2 |
DLX5 |
Distal-less homeobox 5 |
MYBL2 |
MYB proto-oncogene like 2 |
NR4A3 |
Nuclear receptor subfamily 4 group A member 3 |
PKNOX2 |
PBX/knotted 1 homeobox 2 |
GPRASP1 |
G protein-coupled receptor associated sorting protein 1 |
PAH |
Pulmonary arterial hypertension |
DEGs |
Differentially expressed genes |
CpG |
Cytosine–guanine dinucleotides |
DNMT1 |
DNA methyltransferase 1 |
DNMT3A |
DNA methyltransferase 3 Alpha |
DNMT3B |
DNA methyltransferase 3 Beta |
TET |
Ten-eleven translocation family |
FIGN |
Fidgetin, microtubule severing factor |
HTRA3 |
HtrA serine peptidase 3 |
BDNF |
Brain-derived neurotrophic factor |
HCN4 |
Hyperpolarization activated cyclic nucleotide gated potassium channel 4 |
STAC2 |
SH3- and cysteine-rich domain 2 |
SEPT9 |
Septin 9 |
SDC2 |
Syndecan 2 |
MGMT |
O-6-methylguanine-DNA methyltransferase |
NDGR4 |
N-Myc Downstream-Regulated Gene 4 Protein |
BMP3 |
Bone morphogenetic protein 3 |
VIM |
Vimentin |
SFRP |
Secreted frizzled-related protein |
p16 |
Cyclin-dependent kinase inhibitor 2A |
LINE-1 |
Long interspersed nuclear element 1 |
BCAT1/IKZF1 |
Branched-chain amino acid transaminase 1-IKAROS family zinc finger 1 |
RASSF1A |
Ras-association domain family member 1 |
Wnt5A |
Wnt family member 5A |
SFRP2 |
Secreted frizzled-related protein 2 |
DKK2 |
Dickkopf WNT signaling pathway inhibitor 2 |
PCDH10 |
Protocadherin 10 |
TMEFF2 |
Transmembrane protein with EGF-like and two follistatin-like domains 2 |
SFRP1 |
Secreted frizzled-related protein 1 |
HS3ST2 |
Heparan sulfate-glucosamine 3-sulfotransferase 2 |
CDH1/RHOA |
Cadherin 1-ras homolog family member A |
RPRM |
Reprimo, TP53-dependent G2 arrest mediator homolog |
ZNF793 |
Zinc finger protein 793 |
RUNX3 |
Runt-related transcription factor 3 |
PTEN |
Phosphatase and tensin homolog |
CXXC4 |
CXXC finger protein 4 |
TIMP2 |
TIMP metallopeptidase inhibitor 2 |
COL9A2 |
Collagen type IX alpha 2 chain |
EYA1 |
EYA transcriptional coactivator and phosphatase 1 |
ZNF365 |
Zinc finger protein 365 |
AMPH |
Amphiphysin |
SORCS3 |
Sortilin-related VPS10 domain containing receptor 3 |
AJAP1 |
Adherens junctions-associated protein 1 |
TGFβ2 |
Transforming growth factor beta 2 |
SHOX2 |
Short stature homeobox 2 |
RASSF1A |
Ras-association domain family member 1 |
RASSF1A-RARβ2 |
Ras-association domain family member 1–retinoic acid receptor beta 2 |
SHOX2-PTGER4 |
Short stature homeobox 2-prostaglandin E receptor 4 |
p16-RARβ2 |
Cyclin=dependent kinase inhibitor 2A–retinoic acid receptor beta 2 |
DAL-1 |
Erythrocyte membrane protein band 4.1 like 3 |
EPHB6 |
EPH receptor B6 |
HS3ST2 |
Heparan sulfate-glucosamine 3-sulfotransferase 2 |
TMEM88 |
Transmembrane protein 88 |
ELMO3 |
Engulfment and cell motility 3 |
HOXA9 |
Homeobox A9 |
RARβ2 |
Retinoic acid receptor beta 2 |
CDH13 |
Cadherin 13 |
CDKN2A/P16 |
Cyclin-dependent kinase inhibitor 2A |
CASP8 |
Caspase 8 |
TNFRSF6/Fas |
Fas cell surface death receptor |
TRAIL-R1/DR4 |
TNF receptor superfamily member 10a |
SCLC |
Small-cell carcinoma |
cfDNA |
Cell-free DNA |
ANK1 |
Ankyrin 1 |
CCND2 |
Cyclin D2 |
GATA3 |
GATA-binding protein 3 |
KCNH5 |
Potassium voltage gated channel subfamily H member 5 |
RARβ |
Retinoic acid receptor beta |
RASSF1 |
Ras-association domain family member 1 |
CLDN1 |
Claudin 1 |
TP63 |
Tumor protein p63 |
TPX5 |
T-box transcription factor 5 |
ADHFE1 |
Alcohol dehydrogenase iron containing 1 |
HNF1B |
HNF1 homeobox B |
EZH2 |
Enhancer of zeste 2 polycomb-repressive complex 2 subunit |
IBD |
Inflammatory bowel disease |
COPD |
Chronic obstructive pulmonary disease |
PAH-LTRS |
PAH associated with the congenital left-to-right shunt |
CSCs |
Cancer stem cells |
NF-kB |
Nuclear factor kappaB |
STAT3 |
Signal transducer and activator of transcription 3 |
SCFAs |
Short-chain fatty acids |
MUC2 |
Mucin 2, oligomeric mucus/gel-forming |
IL-6 |
Interleukin 6 |
MUC5B |
Mucin 5B, oligomeric mucus/gel-forming |
MUC7 |
Mucin 7, secreted |
IL-1 |
Interleukin 1 |
IL-8 |
Interleukin 8 |
TNF α |
Tumor necrosis factor alpha-like |
GRHL2 |
Grainyhead-like 2 transcription factor |
RhoG |
Ras homology growth |
ZEB1 |
Zinc finger E-box binding homeobox 1 |
MHC |
Major histocompatibility complex |
TLR |
Toll-like receptors |
HLA-A |
Major histocompatibility complex, class I, A |
HLA-B |
Major histocompatibility complex, class I, B |
HLA-C |
Major histocompatibility complex, class I, C |
CD8+ T cells |
Cytotoxic T lymphocytes |
HLA-DP |
Major histocompatibility complex, class II, DP |
HLA-DQ |
Major histocompatibility complex, class II, DQ |
HLA-DR |
Major histocompatibility complex, class II, DR |
CD4+ T cells |
Helper T lymphocytes |
TSA |
Tumor-specific antigen |
CTLA4 |
Cytotoxic T-lymphocyte-associated protein 4 |
APOBEC |
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 3 |
PAMPs |
Pathogen-associated molecular patterns |
PRRs |
Pattern-recognition receptors |
RLRs |
Retinoic acid-inducible gene-I (RIG-I)-like receptors |
ALRs |
Melanoma-2 (AIM2)-like receptors |
CLRs |
C-type lectin receptors |
NLRs |
Nucleotide oligomerization domain (NOD)-like receptors |
MAVS |
Mitochondrial antiviral-signaling protein |
TBK1 |
TANK-binding kinase 1 |
IKKε |
Nuclear factor kappaB kinase-ε |
IRF3 |
Interferon regulatory factor 3 |
IRF7 |
Interferon regulatory factor 7 |
CRD |
Carbohydrate-recognition domain |
CTLD |
C-type lectin-like domain |
Dectin-1 |
C-type lectin 1 |
ITAM |
Immunoreceptor tyrosine-based activation motif |
DC-SIGN |
DC-specific ICAM3-grabbing non-integrin |
NAIP |
NLR family apoptosis inhibitory protein |
CIITA |
Class II major histocompatibility complex transactivator |
HETE |
Cytochrome P450 family 4 subfamily F member 2 |
TP1 |
Transition protein 1 |
TIR |
Toll/IL-1R domain |