Figure 1.

Clinical features of patients with acquired generalised lipodystrophy. Near-total generalised loss of adipose tissue observed in patient #2 at 13 years of age (A), patient #5 at 39 years of age (B), patient #7 at 18 years of age (C), and patient #6 at 2 years and 10 months of age (D). Patient #6 preserves facial fat. Acanthosis nigricans in patient #2 (E). Foot of patient #5 showing severe loss of subcutaneous fat (F). Loss of fat in the lower limb of patient #2 along with phlebomegaly (G).