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. 2023 Nov 30;24(23):16962. doi: 10.3390/ijms242316962

Figure 1.

Figure 1

(A) Similarity alignment of OTX1 and OTX2 proteins. Red boxes represent high similarity protein sequence elaborated using COBALT Constraint-based Multiple Alignment Tool (NCBI). Black boxes represent the Homeobox domain common to the two transcription factors, small boxes the nucleotides involved in the DNA binding. (B) Interactors of OTX1 and OTX2 elaborated with STRING Version 12 software “https://string-db.org/ (accessed on 16 November 2023)”. Network nodes represent proteins, colored nodes represent query proteins (OTX1, 2) and first shell of interactors. The filled nodes indicate when a 3D structure is known or predicted. Edges represent protein–protein associations. The list of interactors has been generated using BioGRID version 4.4.225 “https://thebiogrid.org (accessed on 16 November 2023)”. Only interactors with physical, non-redundant high-throughput (HTP) evidence have been considered.