Table 1.
Baseline characteristics of the study population.
| Cryoprecipitate Group (n = 109) |
Fibrinogen Group (n = 97) |
Total (n = 206) |
p-Value | |
|---|---|---|---|---|
| Demographic data | ||||
| Age | 55.0 (48.0–61.0) | 58.0 (52.0–63.0) | 56.0 (50.0–62.0) | 0.046 |
| Sex, male | 75 (68.1) | 72 (74.2) | 147 (71.4) | 0.481 |
| BMI | 22.9 (20.2–26.0) | 23.7 (21.3–26.9) | 23.2 (20.6–26.4) | 0.101 |
| Diabetes | 32 (29.4) | 31 (32.0) | 63 (30.6) | 0.800 |
| Hypertension | 23 (21.1) | 22 (22.7) | 45 (21.8) | 0.916 |
| CKD | 5 (4.6) | 3 (3.1) | 8 (3.9) | 0.847 |
| CAD | 3 (2.8) | 2 (2.1) | 5 (2.4) | 1.000 |
| CVA | 3 (2.8) | 2 (2.1) | 5 (2.4) | 1.000 |
| MELD-Na score | 18.0 (10.0–27.0) | 15.0 (11.0–21.0) | 17.0 (10.0–24.0) | 0.368 |
| CTP score | 9.0 (7.0–11.0) | 9.0 (7.0–10.0) | 9.0 (7.0–11.0) | 0.538 |
| Cause for LT | ||||
| HBV LC | 43 (39.5) | 37 (38.1) | 80 (38.8) | 0.961 |
| HCV LC | 5 (4.6) | 6 (6.2) | 11 (5.3) | 0.842 |
| Alcoholic LC | 50 (45.9) | 39 (40.2) | 89 (43.2) | 0.497 |
| HCC | 40 (36.7) | 40 (41.2) | 80 (38.8) | 0.600 |
| HCC with HBV | 27 (24.8) | 23 (23.7) | 50 (24.3) | 0.989 |
| HCC with HCV | 4 (3.7) | 6 (6.2) | 10 (4.9) | 0.521 |
| HCC with Alcoholic LC | 7 (6.4) | 12 (12.4) | 19 (9.2) | 0.218 |
| Laboratory variables | ||||
| Hemoglobin, g/dL | 9.3 (8.2–11.0) | 10.2 (8.4–12.0) | 9.9 (8.3–11.7) | 0.052 |
| Platelet, /L | 59.0 (42.0–88.0) | 58.0 (38.0–79.0) | 58.0 (38.0–82.0) | 0.462 |
| INR | 1.49 (1.23–1.86) | 1.38 (1.24–1.65) | 1.42 (1.23–1.75) | 0.110 |
| AST | 38.0 (28.0–56.0) | 37.0 (26.0–52.0) | 38.0 (27.0–54.0) | 0.347 |
| ALT | 21.0 (15.0–34.0) | 21.0 (14.0–28.0) | 21.0 (15.0–32.0) | 0.369 |
| Total bilirubin | 2.9 (1.2–7.7) | 2.0 (1.2–3.4) | 2.2 (1.2–5.2) | 0.082 |
| Albumin, g/dL | 3.0 (2.6–3.4) | 2.9 (2.5–3.4) | 2.9 (2.6–3.4) | 0.496 |
| Sodium | 138.0 (134.0–140.0) | 138.0 (134.0–141.0) | 138.0 (134.0–141.0) | 0.850 |
| Creatinine, mg/dL | 0.85 (0.72–1.15) | 0.78 (0.61–0.98) | 0.82 (0.66–1.06) | 0.036 |
| Intraoperative variables | ||||
| Operation time, hour | 12.5 ± 2.2 | 12.6 ± 1.9 | 12.6 ± 2.1 | 0.816 |
| Crystalloid, mL | 6200.0 (4400.0–8900.0) | 7200.0 (5200.0–9700.0) | 6450.0 (4700.0–9050.0) | 0.187 |
| Colloid, mL | 3600.0 (2800.0–4800.0) | 4000.0 (2800.0–5600.0) | 3600.0 (2800.0–5200.0) | 0.190 |
| Urine output, mL | 1570.0 (1010.0–2350.0) | 2000.0 (1400.0–2690.0) | 1755.0 (1200.0–2580.0) | 0.006 |
Note: values are expressed as the mean ± SD, number (%), or median (1Q, 3Q). Abbreviations: BMI, body mass index; CKD, chronic kidney disease; CAD, coronary artery disease; CVA, cerebrovascular accident; MELD-Na, Model for End-stage Liver Disease-Sodium; CTP, Child–Turcotte–Pugh; LT, liver transplantation; LC, liver cirrhosis; HCC, hepatocellular carcinoma; INR, international normalized ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase.