Table 2.
Details of intraoperative transfusion and intervention.
| Cryoprecipitate Group (n = 109) |
Fibrinogen Group (n = 97) |
Total (n = 206) |
p-Value | |
|---|---|---|---|---|
| Intraoperative transfusion | ||||
| pRBC (unit) | 10.0 (6.0–18.0) | 10.0 (5.0–17.0) | 10.0 (6.0–18.0) | 0.757 |
| FFP (unit) | 10.0 (4.0–14.0) | 10.0 (6.0–18.0) | 10.0 (5.0–16.0) | 0.461 |
| Platelet apheresis (unit) | 1.0 (0.0–1.0) | 1.0 (0.0–1.0) | 1.0 (0.0–1.0) | 0.990 |
| Fibrinogen (g) | 0.0 (0.0–0.0) | 2.0 (2.0–4.0) | 0.0 (0.0–2.0) | <0.001 |
| Cryoprecipitate (unit) | 10.0 (10.0–10.0) | 0.0 (0.0–0.0) | 5.0 (0.0–10.0) | <0.001 |
| Massive transfusion | 57 (52.3) | 54 (55.7) | 111 (53.9) | 0.730 |
| Baseline | ||||
| Fibrinogen in plasma (mg/dL) | 75.0 (60.0–86.0) | 78.0 (62.0–96.0) | 77.0 (60.0–91.0) | 0.206 |
| FIBTEM | ||||
| MA 10 (mm) | 4.0 (3.0–6.0) | 4.0 (3.0–6.0) | 4.0 (3.0–6.0) | 0.521 |
| MCF (mm) | 4.0 (3.0–7.0) | 5.0 (4.0–7.0) | 5.0 (3.0–7.0) | 0.479 |
| After treatment for acquired hypofibrinogenemia | ||||
| Fibrinogen in plasma (mg/dL) | 97.0 (78.0–120.0) | 100.0 (81.0–116.0) | 98.0 (80.0–118.0) | 0.838 |
| FIBTEM | ||||
| MA 10 (mm) | 4.0 (3.0–6.0) | 5.0 (3.0–6.0) | 5.0 (3.0–6.0) | 0.033 |
| MCF (mm) | 4.0 (3.0–6.0) | 5.0 (4.0–7.0) | 5.0 (3.0–7.0) | 0.019 |
| Fibrinogen administered | ||||
| Preanhepatic | 21 (19.3) | 25 (25.8) | 46 (22.3) | 1.000 |
| Anhepatic | 12 (11.0) | 2 (2.1) | 14 (6.8) | |
| Postreperfusion | 76 (69.7) | 70 (72.2) | 146 (70.9) | |
Note: values are expressed as median (1Q, 3Q) or number (%). Abbreviations: pRBC, packed red blood cell; FFP, fresh frozen plasma; FIBTEM, assay for tissue factor activation and platelet inhibition; MA 10, maximum amplitude at 10 min; MCF, maximum clot firmness.