Caths	Cathepsins
RT	Radiation therapy
Caco-2	Colon Carcinoma Cells
CRISPR	Clustered regularly interspaced short palindromic repeats
CRC	Colorectal cancer
SSBs	Single-strand breaks
DSBs	Double-strand breaks
IR	Ionizing radiation
Gy	Gray
SDS-PAGE	Sodium dodecyl-sulfate polyacrylamide gel electrophoresis
SE	Standard error
DAPI	4′,6-diamidino-2-phenylindole
kDa	Kilodalton
WT	Wild type
DMEM	Dulbecco’s Modified Eagle Medium
ROS	Reactive Oxygen Species
DDR	DNA damage response
NHEJ	Non-homologous end-joining
HR	Homologous recombination