Table 2.
MicroRNAs deregulated in non-tumorigenic human cell lines and tissues, and normal mouse lung tissue on exposure to PAHs.
| Pollutant | Tissue/Cell Type | Regulation Up/Down | Potential Target/Regulatory Mechanism | Reference |
|---|---|---|---|---|
| DEP/PM | Human bronchial cells |
Up: miR-513c, miR-513b, miR-513a-5p, miR-923, miR-494, miR-338-5p Down: miR-26b, miR-27a, miR-31, miR-96, miR-135b, miR-374a |
Diana not validated CD274, immunology Fragment of 28S RNA PTEN ABC Transporters P53, TGF-β Apoptosis Inflammation DICER, ATM |
[148] |
| DEP/PM | Primary pFBEC cells | Up: miR-375 | TSLP, AhR, immunity |
[150] |
| BPDE | BEAS-2B cells and mouse | Up: miR-205 | PHLPP2 | [153] |
| DEP/PM | Human lung tissue |
Up: miR-21-5p, miR-29a-3p, miR-29b-3p, miR-30d-5p, miR-223-3p, miR-4454 Down: miR-34c-3p, miR-98, miR-125b-5p, miR-140-5p, miR-181a-5p, miR-181b/d-5p, miR-197-3p, miR-331-3p, miR-423-3p, miR-425-5p |
Diana not validated | [155] |
| B[a]P | Mouse lung tissue |
Up: miR-34c, miR- 34b -5p, miR-29b, miR-141, miR-199a -5p, miR-125a-5p, miR-200c Down: miR-122, miR-142-3p, mi-144, miR-142-5p, miR-150, miR-451 |
Oxidative stress, Xenobiotic metabolism, inflammation | [86] |
| B[a]P | BEAS-2B cells | Up: miR-30c-1-3p | TGFβR2 | [149] |
| CBNPs | Mouse lung tissue |
Up: miR-21, miR-135b, miR-146b |
Cellular apoptosis, oxidative stress, inflammation | [146] |
| nCB | Mouse lung issue cells |
Up:miR-22 | HDAC4 | [160] |
| VOCs | Mouse lung tissue |
Up: miR-1187, miR-125a-3p, miR-125b-5p, miR-466c-5p, miR-5105, miR- 3472 | Cell cycle, apoptosis, inflammatory response | [161] |
BPDE: Benzo[a]pyrene-diolepoxide; B[a]P: Benzo[a]pyrene; CBNPs: carbon nanoparticles; nCB: Black carbon nanoparticles; BEAS-2B: human bronchial epithelium cells; VOCs: volatile organic compounds; pHBEC: primary cells of human bronchial epithelium; HDAC4: Histone deacetylase 4; DEP/PM: Diesel engine emission particles in particulate matter.