Table 3.
MicroRNAs deregulated by exposure to PAHs in cell lines of lung cancer or neoplastic tissues or benzo(a)pyrene-transformed bronchial epithelial cells.
| Pollutant | Tissue/Cell Type | microRNA Expression: Up/Down Regulation | Potential Target/Pathway |
Reference |
|---|---|---|---|---|
| anti-BPDE | Cell line (16HBE-T) |
Down: miR-10a | HOXA1 | [165] |
| anti-BPDE | Cell line (16HBE-T) |
Up: miR-494 | PTEN | [167] |
| anti-BPDE | Cell line (16HBE-T) |
Up: miR-22 | PTEN | [168] |
| anti-BPDE | Cell line (16HBE-T) |
Up: miR-622 | KRAS | [178] |
| B[a]P | Mouse lung tissue |
Up: miR-320, miR-494 | CDK6 | [170] |
| B[a]P | HBE-1A1 cells | Down: miR-3173-5p Up: miR-1343-3p, miR-27a-5p, miR-219a-1-3p |
CDKN1A, MAPK13, ALDH1A3 SMAD2 CYP1A1 IL1A and IL1B |
[184] |
| B[a]P | BEAS-2B cells | Up: miR-377-3p | Wnt/β-catenin pathway via EGR1 downregulation | [185] |
| Β[a]P | Primary lung tumors |
Down: miR-34b | α4 | [156] |
| B[a]P | Cell line (BEAS-2B) |
Down: miR-138-5p | PDGFRB, IncRNA RGMB-AS1 and circ-ZNF292 | [179] |
| B[a]P | Cell line (16HBE-T) |
Down: miR-152-3p, miR-142-5p and miR-211-5p | ALCAM | [182] |
| B[a]P | Mouse lung tissue |
Down: miR-101 | IL-1β and Lin28B | [162] |
| BPDE | Cell line (A-549) |
Down: miR-29a | Cdc7 | [172] |
| anti-BPDE | Cell line (16HBE-T) |
Down: miR-506 | N-Ras | [173] |
| anti-BPDE | Cell line (16HBE-T) |
Down: miR-542-3p | Cellular cycle | [174] |
| B[a]P | Cell line (HBER) |
Up: miR-638 | BRCA1 | [175] |
| nCB | Cell line (A549) |
Down: miR-144 | ZEB1 | [176] |
| BPDE | Cell line (BEAS-2B), (A549) |
Up: miR-205 | PHLPP2 | [153] |
| DEP | Cell line (A549), (H358) |
Up: miR-155 | UBQLN1, UBQLN2 | [180] |
| NaP, Acy, Ace, Ant, Flu, Pyr, BaA, Chr, BbF, BkF, B[a]P and DBA | Cell line A549 | Up: miR-222, miR-210, miR-101, miR-34, miR-93 and miR-200a | NFKB, MYCN, CDKN1A, CDKN1B, RAD52, BAG1 | [38] |
anti-BPDE: anti-benzo[a]pyreno-7, 8-diol-9,10-epoxide; A549: human lung carcinoma cell line; B[a]P: Benzo[a]pyrene; BPDE: Benzo[a]pyrene-diolepoxide; NaP: Napthalene; Acy: Acenapthylene; Ace: Acenapthene; Ant: Anthracene; Fl: Fluorene; Pyr: Pyrene; BaA: Benzo(a)anthracene; Chr: Chrysene; BbF: Benzo(b)fluoranthene; BkF: Benzo(k)fluoranthene; DBA: Dibenzo(a,h)anthracene; DEP: Diesel engine emission particles; nCB: Black carbon nanoparticles; H358: human bronchioalveolar carcinoma cell line; 16HBE-T: Transformed human bronchial epithelium cell line; HBER: human bronchial epithelial cells expressing the oncogenic H-Ras allele.