Table 5.
Meta-analysis for postoperative complications (remimazolam–flumazenil vs. propofol).
| Postoperative Complication | No of Studies | No of Patients | Effect Model | Method | I2 (%) | Results of Meta-Analyses | Certainty | |
|---|---|---|---|---|---|---|---|---|
| MD (95% CI) | p Value | |||||||
| Pain | 2 ! | 135 | Fixed | I-V | 0 | −0.01 (−0.08, 0.06) | 0.78 | High |
| RR (95% CI) | p value | |||||||
| PONV | 7 | 587 | Fixed | M-H | 0 | 0.87 (0.49, 1.56) | 0.64 | High |
| Respiratory depression | 4 | 311 | Fixed | M-H | 0 | 0.2 (0.04, 0.89) | 0.03 * | High |
| Emergence agitation | 4 | 291 | Fixed | M-H | 0 | 0.45 (0.1, 1.94) | 0.28 | Moderate |
| Re-sedation | 4 | 289 | Fixed | M-H | 35.07 | 4.15 (1.31, 13.13) | 0.01 * | Moderate |
| Delirium | 3 | 172 | Fixed | M-H | 0 | 0.67 (0.11, 3.87) | 0.65 | Low |
| Dizziness | 2 | 135 | Fixed | M-H | 0 | 0.42 (0.11, 1.57) | 0.2 | Moderate |
!: A study was excluded because it reported the median and interquartile range for postoperative pain scores [44], which, after data transformation, yielded a standard deviation of 0; *: p < 0.05; MD: mean difference; RR: risk ratio; CI: confidence interval; I-V: Inverse-Variance; M-H: Mantel–Haenszel; PONV: postoperative nausea and vomiting.