. 2023 Nov 30;24(23):16960. doi: 10.3390/ijms242316960

Table 1.

Properties of the eight antibiotics assayed *.

Antibiotic Name	Abbr.	Family	CAS Number	MW (g/mol)	Water Solubility (mg/mL)	pKa		Log Ko/w	1000 µg/mL
Antibiotic Name	Abbr.	Family	CAS Number	MW (g/mol)	Water Solubility (mg/mL)	pKa1	pKa2	Log Ko/w	C_max ⁽¹⁾	r ⁽²⁾
Chloramphenicol	CHL	Amphenicols	56-75-7	323.1	2.5	7.5	−2.8	1.0	0.133	0.067
Tetracycline	TC	Tetracyclines	64-75-5	444.4	75.5	3.3	9.2	−2.0	1.801	0.070
Erythromycin	ERY	Macrolides	114-07-8	733.9	2.0	8.9	8.9	−3.0	0.645	0.043
Streptomycin sulphate	STM	Aminoglycosides	3810-74-0	581.6	75.0	10.9	12.0	−5.2	0.602	0.037
Gentamycin sulphate	GTM	Aminoglycosides	1405-41-0	447.6	50.0	12.6	10.1	−2.4	0.420	0.035
Amoxicillin	AMO	Beta-lactams	26787-78-0	356.4	1.0	2.9	11.7	0.9	0.645	0.043
Ampicillin	AMP		69-53-4	349.4	10.0	2.6	7.2	1.4	0.640	0.037
Penicillin G sodium salt	PEN		69-57-8	356.4	75.0	3.5	−2.8	1.2	0.650	0.042
Control									1.081	0.043

* Physicochemical properties were obtained from PubChem and ChemicalBook databases. Cmax and r were obtained from the 1000 μg/mL AWCD curves. ⁽¹⁾ Maximum achievable population density (carrying capacity). ⁽²⁾ Intrinsic rate of population growth.