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. 2023 Dec 3;24(23):17085. doi: 10.3390/ijms242317085

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Neural crest development. The figure highlights key gene regulatory networks shaping neural crest induction, NCC specification, migration, and differentiation. The graph illustrates varying MYCN protein expression levels during normal NCC development (black line) and in MNA NB (red line). MYCN amplification might occur during early NCC migration or sympathetic lineage specification, leading to NB formation. Epigenetic mechanisms (miRNAs, histone methylation, and chromatin remodeling) regulating MYCN expression are also captured [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37]. (SG: sympathetic ganglia). Created with Biorender.com, accessed on 3 November 2023.