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. 2023 Dec 3;24(23):17085. doi: 10.3390/ijms242317085

Figure 2.

Figure 2

Early stages of NB development from NCCs. NB tumors exhibit two super-enhancer (SE)-associated cell types: committed adrenergic (ADRN) and undifferentiated mesenchymal (MES) cell types, originating from bipotent progenitors. These cells can spontaneously interconvert into one another via epigenetic mechanisms. This bidirectional conversion is controlled by core regulatory circuitries, where core TFs bind to their own SEs and each other’s SEs, creating feed-forward transcriptional loops that underlie lineage identity. The main core ADRN and MES SE-associated TFs are listed in the blue boxes. SEs were identified using genome-wide profiling of histone H3 lysine 27 acetylation (H3K27ac) enhancer signature in NB tumors and cell lines [18,25]. Created with Biorender.com, accessed on 5 October 2023.