Table 3.

Regulators of histone marks in MNA NB.

Gene	Role	Methylation/Acetylation in MNA NB	Expression in MNA NB	Citation
EP300	HAT	H3K27 acetylation	Increased	[69,70]
HDAC2	HDAC	Deacetylates MIR183 promoter	Increased	[74]
HDAC5	HDAC	Deacetylates CD9	Increased	[75]
SIRT1	HDAC	Deacetylation of tumor suppressors	Increased	[72]
HDAC1	HDAC	Deacetylates NTRK1 promoter	Unknown	[73]
DOT1L	HMT	H3K79 methylation	Increased	[76]
EZH2	Catalytic subunit of PRC2 complex	H3K27 trimethylation	Increased	[37,55]
KDM4B	Histone demethylase	H3K9me3/me2 demethylation	Increased	[77]
PRMT5	HMT	H3R8 and H4R3 dimethylation	Increased	[78]
WDR5	Histone H3K4 presenter	H3K4 trimethylation	Increased	[79]